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首页> 外文期刊>Experimental and therapeutic medicine >Therapeutic effect of photodynamic therapy combined with imiquimod in the treatment of anal condyloma acuminatum and its effect on immune function
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Therapeutic effect of photodynamic therapy combined with imiquimod in the treatment of anal condyloma acuminatum and its effect on immune function

机译：光动力治疗与咪喹莫特联合治疗肛肠尖锐湿疣的治疗疗效及其对免疫功能的影响

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摘要

Therapeutic effect of photodynamic therapy combined with imiquimod in the treatment of anal condyloma acuminatum (CA) was investigated to explore its effect on immune function. A total of 104 patients with anal CA were randomly divided into two groups: Patients in the study group were treated with photodynamic therapy combined with imiquimod, and ii) patients in the control group were treated with recombinant human interferon alpha-2b cream. Clinical efficacy and immune function related indicators were compared between the two groups. After treatment for 6 weeks, the cure rate and total effective rate of study group was 53.85 and 92.31%, respectively, which were significantly higher than those of the control group (30.77 and 75.00%, P0.05). Recurrence rate of study group was 3.85% within 6 months after treatment, which was significantly lower than that of the control group (19.23%, P0.05). After treatment, levels of CD4(+), CD4(+)/CD8(+) and IFN-gamma in the study group were significantly higher than those in the control group, and levels of CD8(+), IL-4 and IL-10 in the study group were significantly lower than those in the control group (P0.05). Photodynamic therapy combined with imiquimod in the treatment of anus CA can regulate T lymphocyte subsets and cytokine levels, enhance immune function, improve clinical efficacy, reduce recurrence rate, and have almost no side effects. Therefore, this treatment should be popularized in clinical practice.
机译：研究了光动力治疗与咪喹莫特联合治疗肛肠尖锐湿疣（CA）的治疗探讨其对免疫功能的影响。总共104例肛门CA患者随机分为两组：研究组的患者用光动力治疗与咪喹莫特相结合，II）对照组患者用重组人干扰素α-2B乳膏治疗。两组比较临床疗效和免疫功能相关指标。治疗6周后，研究组的固化率和总有效率分别为53.85和92.31％，显着高于对照组（30.77和75.00％，P <0.05）。治疗后6个月内的研究组的复发率为3.85％，显着低于对照组（19.23％，P <0.05）。治疗后，研究组中CD4（+），CD4（+）/ CD8（+）和IFN-γ的水平明显高于对照组的水平，以及CD8（+），IL-4和IL的水平-10在研究组中显着低于对照组（P <0.05）中的那些。光动力治疗联合咪喹莫特治疗肛门CA可以调节T淋巴细胞亚群和细胞因子水平，增强免疫功能，提高临床疗效，降低复发率，几乎没有副作用。因此，这种治疗应该在临床实践中普及。

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