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首页> 美国卫生研究院文献>Journal of Biomechanical Engineering >Combining IVUS and Optical Coherence Tomography for More Accurate Coronary Cap Thickness Quantification and Stress/Strain Calculations: A Patient-Specific Three-Dimensional Fluid-Structure Interaction Modeling Approach
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Combining IVUS and Optical Coherence Tomography for More Accurate Coronary Cap Thickness Quantification and Stress/Strain Calculations: A Patient-Specific Three-Dimensional Fluid-Structure Interaction Modeling Approach

机译：结合IVUS和光学相干断层扫描技术以更准确地测量冠状动脉冠层厚度并进行应力/应变计算：一种针对患者的三维流体结构相互作用建模方法

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Accurate cap thickness and stress/strain quantifications are of fundamental importance for vulnerable plaque research. Virtual histology intravascular ultrasound (VH-IVUS) sets cap thickness to zero when cap is under resolution limit and IVUS does not see it. An innovative modeling approach combining IVUS and optical coherence tomography (OCT) is introduced for cap thickness quantification and more accurate cap stress/strain calculations. In vivo IVUS and OCT coronary plaque data were acquired with informed consent obtained. IVUS and OCT images were merged to form the IVUS + OCT data set, with biplane angiography providing three-dimensional (3D) vessel curvature. For components where VH-IVUS set zero cap thickness (i.e., no cap), a cap was added with minimum cap thickness set as 50 and 180 μm to generate IVUS50 and IVUS180 data sets for model construction, respectively. 3D fluid–structure interaction (FSI) models based on IVUS + OCT, IVUS50, and IVUS180 data sets were constructed to investigate cap thickness impact on stress/strain calculations. Compared to IVUS + OCT, IVUS50 underestimated mean cap thickness (27 slices) by 34.5%, overestimated mean cap stress by 45.8%, (96.4 versus 66.1 kPa). IVUS50 maximum cap stress was 59.2% higher than that from IVUS + OCT model (564.2 versus 354.5 kPa). Differences between IVUS and IVUS + OCT models for cap strain and flow shear stress (FSS) were modest (cap strain <12%; FSS <6%). IVUS + OCT data and models could provide more accurate cap thickness and stress/strain calculations which will serve as basis for further plaque investigations.
机译：准确的瓶盖厚度和应力/应变定量对于易损斑块研究至关重要。虚拟组织学血管内超声（VH-IVUS）可在帽低于分辨率极限且IVUS看不到时将帽厚度设为零。引入了一种创新的建模方法，将IVUS和光学相干断层扫描（OCT）相结合，用于盖厚度量化和更准确的盖应力/应变计算。在获得知情同意的情况下，获取了体内IVUS和OCT冠状动脉斑块数据。 IVUS和OCT图像合并形成IVUS ++ OCT数据集，双平面血管造影可提供三维（3D）血管曲率。对于VH-IVUS设置为零瓶盖厚度（即无瓶盖）的组件，添加了一个最小瓶盖厚度设置为50和180μm的瓶盖，以分别生成用于模型构建的IVUS50和IVUS180数据集。建立基于IVUS + OCT，IVUS50和IVUS180数据集的3D流体-结构相互作用（FSI）模型，以研究盖厚度对应力/应变计算的影响。与IVUS ++ OCT相比，IVUS50低估了平均瓶盖厚度（27个切片）34.5％，高估了平均瓶盖应力45.8％（96.4 vs 66.1 kPa）。 IVUS50的最大瓶盖应力比IVUS ++ OCT模型的最高应力高59.2％（564.2对354.5 kPa）。 IVUS和IVUS + OCT模型在帽盖应变和流动剪切应力（FSS）之间的差异不大（帽盖应变<12％； FSS <6％）。 IVUS + OCT数据和模型可以提供更准确的瓶盖厚度和应力/应变计算，这将为进一步的牙菌斑研究奠定基础。

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