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首页> 美国卫生研究院文献>Journal of Biomechanical Engineering >SIMULATING THE GROWTH OF ARTICULAR CARTILAGE EXPLANTS IN A PERMEATION BIOREACTOR TO AID IN EXPERIMENTAL PROTOCOL DESIGN
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SIMULATING THE GROWTH OF ARTICULAR CARTILAGE EXPLANTS IN A PERMEATION BIOREACTOR TO AID IN EXPERIMENTAL PROTOCOL DESIGN

机译：模拟渗透生物反应器中关节软骨突部的生长以辅助实验方案设计

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Recently a cartilage growth finite element model (CGFEM) was developed to solve non-homogeneous and time-dependent growth boundary value problems [, ]. The CGFEM allows distinct stress constitutive equations and growth laws for the major components of the solid matrix, collagens and proteoglycans. The objective of the current work was to simulate in vitro growth of articular cartilage explants in a steady-state permeation bioreactor in order to obtain results that aid experimental design. The steady-state permeation protocol induces different types of mechanical stimuli: when the specimen is initially homogeneous it directly induces homogeneous permeation velocities and indirectly induces non-homogeneous solid matrix shear stresses; consequently, the steady-state permeation protocol is a good candidate for exploring two competing hypotheses for the growth laws. The analysis protocols were implemented through the alternating interaction of the two CGFEM components: poroelastic FEA using ABAQUS and a finite element growth routine using MATLAB. The CGFEM simulated 12 days of growth for immature bovine articular cartilage explants subjected to two competing hypotheses for the growth laws: one that is triggered by permeation velocity and the other by maximum shear stress. The results provide predictions for geometric, biomechanical, and biochemical parameters of grown tissue specimens that may be experimentally measured and, consequently, suggest key biomechanical measures to analyze as pilot experiments are performed. The combined approach of CGFEM analysis and pilot experiments may lead to the refinement of actual experimental protocols and a better understanding of in vitro growth of articular cartilage.
机译：最近，软骨生长有限元模型（CGFEM）被开发用于解决非均匀且随时间变化的生长边界值问题[，]。 CGFEM为固体基质的主要成分，胶原蛋白和蛋白聚糖提供了独特的应力本构方程和生长规律。当前工作的目的是模拟稳态渗透生物反应器中关节软骨外植体的体外生长，以获得有助于实验设计的结果。稳态渗透方案引起不同类型的机械刺激：当样品最初是均质的时，它直接引起均质的渗透速度，并间接地引起非均质的固体基质剪切应力。因此，稳态渗透协议是探索增长规律的两个相互竞争的假设的理想选择。通过两个CGFEM组件的交替交互来实现分析协议：使用ABAQUS的多孔弹性有限元分析和使用MATLAB的有限元生长程序。 CGFEM针对未成熟的牛关节软骨外植体模拟了12天的生长，对它们的生长规律进行了两个相互竞争的假设：一个是由渗透速度触发的，另一个是由最大剪切应力触发的。结果为可以通过实验测量的生长组织标本的几何，生物力学和生化参数提供了预测，因此，建议在进行中试实验时进行分析的关键生物力学措施。 CGFEM分析和先导实验相结合的方法可能会导致实际实验方案的完善和对关节软骨体外生长的更好理解。

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