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首页> 美国卫生研究院文献>Journal of Applied Physiology >Characterization of cardiovascular reflexes evoked by airway stimulation with allylisothiocyanate capsaicin and ATP in Sprague-Dawley rats
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Characterization of cardiovascular reflexes evoked by airway stimulation with allylisothiocyanate capsaicin and ATP in Sprague-Dawley rats

机译：异硫氰酸烯丙酯辣椒素和ATP对气道刺激引起的心血管反射的特征

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Acute inhalation of airborne pollutants alters cardiovascular function and evidence suggests that pollutant-induced activation of airway sensory nerves via the gating of ion channels is critical to these systemic responses. Here, we have investigated the effect of capsaicin [transient receptor potential (TRP) vanilloid 1 (TRPV1) agonist], AITC [TRP ankyrin 1 (TRPA1) agonist], and ATP (P2X2/3 agonist) on bronchopulmonary sensory activity and cardiovascular responses of conscious Sprague-Dawley (SD) rats. Single fiber recordings show that allyl isothiocyanate (AITC) and capsaicin selectively activate C fibers, whereas subpopulations of both A and C fibers are activated by stimulation of P2X2/3 receptors. Inhalation of the agonists by conscious rats caused significant bradycardia, atrioventricular (AV) block, and prolonged PR intervals, although ATP-induced responses were lesser than those evoked by AITC or capsaicin. Responses to AITC were inhibited by the TRP channel blocker ruthenium red and the muscarinic antagonist atropine. AITC inhalation also caused a biphasic blood pressure response: a brief hypertensive phase followed by a hypotensive phase. Atropine accentuated the hypertensive phase, while preventing the hypotension. AITC-evoked bradycardia was not abolished by terazosin, the α1-adrenoceptor inhibitor, which prevented the hypertensive response. Anesthetics had profound effects on AITC-evoked bradycardia and AV block, which was abolished by urethane, ketamine, and isoflurane. Nevertheless, AITC inhalation caused bradycardia and AV block in paralyzed and ventilated rats following precollicular decerebration. In conclusion, we provide evidence that activation of ion channels expressed on nociceptive airway sensory nerves causes significant cardiovascular effects in conscious SD rats via reflex modulation of the autonomic nervous system.
机译：急性吸入空气中的污染物会改变心血管功能，证据表明，污染物通过离子通道的门控引起的气道感觉神经激活对于这些全身反应至关重要。在这里，我们研究了辣椒素[瞬态受体电位（TRP）香草素1（TRPV1）激动剂]，AITC [TRP锚蛋白1（TRPA1）激动剂]和ATP（P2X2 / 3激动剂）对支气管肺感觉活性和心血管反应的影响有意识的Sprague-Dawley（SD）大鼠。单纤维记录表明，异硫氰酸烯丙酯（AITC）和辣椒素可以选择性激活C纤维，而A和C纤维的亚群都可以通过刺激P2X2 / 3受体来激活。有意识的大鼠吸入激动剂会导致明显的心动过缓，房室传导阻滞和延长的PR间隔，尽管ATP引起的反应比AITC或辣椒素引起的反应要小。 TRP通道阻滞剂钌红和毒蕈碱拮抗剂阿托品抑制了对AITC的反应。吸入AITC还会引起两相血压反应：短暂的高血压期，然后是降压期。阿托品增强了高血压期，同时防止了低血压。不能将AITC引起的心动过缓由α1肾上腺素受体抑制剂terazosin消除，后者可以预防高血压反应。麻醉剂对AITC引起的心动过缓和房室传导阻滞具有深远的影响，而氨基甲酸酯，氯胺酮和异氟烷已将其取消。然而，人工吸入的AITC会在前脑小脑瘫痪后的瘫痪和通气大鼠中引起心动过缓和房室传导阻滞。总之，我们提供的证据表明，通过伤害性自主神经系统的反射调节，伤害性气道感觉神经上表达的离子通道的激活在自觉SD大鼠中引起明显的心血管效应。

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