• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of applied physiology >Characterization of cardiovascular reflexes evoked by airway stimulation with allylisothiocyanate, capsaicin, and ATP in Sprague-Dawley rats
【24h】

Characterization of cardiovascular reflexes evoked by airway stimulation with allylisothiocyanate, capsaicin, and ATP in Sprague-Dawley rats

机译：通过烯丙基硫氰酸盐，辣椒素，辣椒素和ATP在Sprague-Dawley大鼠中引起心血管反射的表征

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Acute inhalation of airborne pollutants alters cardiovascular function and evidence suggests that pollutant-induced activation of airway sensory nerves via the gating of ion channels is critical to these systemic responses. Here, we have investigated the effect of capsaicin [transient receptor potential (TRP) vaniUoid 1 (TRPV1) agonist], AITC [TRP ankyrin 1 (TRPA1) agonist], and ATP (P2X2/3 agonist) on bronchopulmonary sensory activity and cardiovascular responses of conscious Sprague-Dawley (SD) rats. Single fiber recordings show that allyl isothiocyanate (AITC) and capsaicin selectively activate C fibers, whereas subpopulations of both A and C fibers are activated by stimulation of P2X2/3 receptors. Inhalation of the agonists by conscious rats caused significant bradycardia, atrioventricular (AV) block, and prolonged PR intervals, although ATP-induced responses were lesser than those evoked by AITC or capsaicin. Responses to AITC were inhibited by the TRP channel blocker ruthenium red and the muscarinic antagonist atropine. AITC inhalation also caused a bipha-sic blood pressure response: a brief hypertensive phase followed by a hypotensive phase. Atropine accentuated the hypertensive phase, while preventing the hypotension. AITC-evoked bradycardia was not abolished by terazosin, the alpha_1-adrenoceptor inhibitor, which prevented the hypertensive response. Anesthetics had profound effects on AITC-evoked bradycardia and AV block, which was abolished by urethane, ketamine, and isoflurane. Nevertheless, AITC inhalation caused bradycardia and AV block in paralyzed and ventilated rats following precollicular decer-ebration. In conclusion, we provide evidence that activation of ion channels expressed on nociceptive airway sensory nerves causes significant cardiovascular effects in conscious SD rats via reflex modulation of the autonomic nervous system.
机译：急性吸入空气中的污染物改变了心血管功能，证据表明，污染物诱导通过离子通道的浇注激活气道感觉神经对这些全身反应至关重要。在这里，我们研究了辣椒素[瞬态受体电位（TRP）Vaniuoid 1（TRPV1）Agonist]，Aitc [Trp Ankyrin 1（TRPA1）激动剂]和ATP（P2X2 / 3激动剂）对支气管肺肺肺部感官活性和心血管反应的影响意识到的Sprague-Dawley（SD）大鼠。单纤维记录显示烯丙基异硫氰酸酯（AITC）和辣椒素选择性地激活C纤维，而通过刺激P2X2 / 3受体激活A和C纤维的亚群。通过有意识的大鼠吸入激动剂引起了显着的心动过缓，房室（AV）块和延长的PR间隔，尽管ATP诱导的反应比Aitc或辣椒素引起的那么小。 TRP通道阻滞剂钌和毒蕈碱拮抗剂阿特洛汀抑制了对AITC的反应。 AITC吸入还引起了Biph-SiC血压反应：短暂的高血压阶段，然后是低血压阶段。阿托品突出了高血压阶段，同时防止了低血压。 α1-肾上腺素受抑制剂的α_1-肾上腺素受抑制剂没有废除Aitc诱发的心动过缓，这阻止了高血压反应。麻醉剂对AITC诱发的心动过缓和AV嵌段对氨基甲酸酯，氯胺酮和异氟醚消除的AV嵌段产生了深远的影响。然而，AITC吸入引起了瘫痪和通风大鼠的Bradycardia和AV嵌段，如前所述。总之，我们提供了证据，即在伤害性气道感觉神经上表达的离子通道的激活会通过自主神经系统的反射调节引起有意识的SD大鼠的显着心血管作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号