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首页> 美国卫生研究院文献>Journal of Applied Physiology >Prevention of deep tissue injury through muscle contractions induced by intermittent electrical stimulation after spinal cord injury in pigs
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Prevention of deep tissue injury through muscle contractions induced by intermittent electrical stimulation after spinal cord injury in pigs

机译：通过猪脊髓损伤后间歇性电刺激引起的肌肉收缩来预防深层组织损伤

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Deep tissue injury (DTI) is a severe medical complication that commonly affects those with spinal cord injury. It is caused by prolonged external loading of the muscles, entrapping them between a bony prominence and the support surface. The entrapment causes excessive mechanical deformation and increases in interstitial pressure, leading to muscle breakdown deep around the bony prominences. We proposed the use of intermittent electrical stimulation (IES) as a novel prophylactic method for the prevention of DTI. In this study, we assessed the long-term effectiveness of this technique in pigs that had received a partial spinal cord injury that paralyzed one hindlimb. The pigs recovered for 2 wk postsurgery, and subsequently, their paralyzed limbs were loaded to 25% of their body weights 4 h/day for 4 consecutive days each week for 1 mo. One group of pigs (n = 3) received IES during the loading, whereas another group (n = 3) did not. DTI was quantified using magnetic resonance imaging (MRI) and postmortem histology. In the group that did not receive IES, MRI assessments revealed signs of tissue damage in 48% of the volume of the loaded muscle. In the group that did receive IES, only 8% of the loaded muscle volume showed signs of tissue damage. Similar findings were found through postmortem histology. This study demonstrates, for the first time, that IES may be an effective technique for preventing the formation of DTI in loaded muscles after spinal cord injury.
机译：深层组织损伤（DTI）是一种严重的医学并发症，通常会影响脊髓损伤的患者。这是由于长时间的外部肌肉负荷，使它们陷入骨隆起和支撑表面之间。截留会导致过度的机械变形并增加组织间压力，从而导致骨突起周围深处的肌肉破裂。我们提出使用间歇性电刺激（IES）作为预防DTI的新型预防方法。在这项研究中，我们评估了这项技术在部分脊髓损伤并瘫痪一只后肢的猪中的长期有效性。猪在术后2周恢复了健康，随后，瘫痪的肢体每天连续4天每天4小时/天被加载到其体重的25％，持续1个月。一组猪（n = 3）在加载过程中接受了IES，而另一组猪（n = 3）则没有。 DTI使用磁共振成像（MRI）和验尸组织学进行定量。在未接受IES的组中，MRI评估显示有48％的受累肌肉组织受损迹象。在接受IES治疗的组中，只有8％的肌肉负荷表现出组织损伤的迹象。通过死后组织学发现类似的发现。这项研究首次证明了IES可能是防止脊髓损伤后负重肌肉中DTI形成的有效技术。

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