• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>The Journal of General Virology >A naturally occurring human/hepatitis E recombinant virus predominates in serum but not in faeces of a chronic hepatitis E patient and has a growth advantage in cell culture
【2h】

A naturally occurring human/hepatitis E recombinant virus predominates in serum but not in faeces of a chronic hepatitis E patient and has a growth advantage in cell culture

机译：天然存在的人/戊型肝炎重组病毒在血清中占主导地位而在慢性戊型肝炎患者的粪便中则不常见并且在细胞培养中具有增长优势

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Hepatitis E virus is the aetiological agent of acute hepatitis E, a self-limiting disease prevalent in developing countries. Molecular analysis of viral genomic RNA from a chronically infected patient confirmed the recent discovery that chronic infection correlated with extensive diversification of the virus quasispecies: the hypervariable region of some virus genomes in this USA patient contained large continuous deletions and a minor proportion of genomes in faeces and serum had acquired a mammalian sequence that encoded 39 aa of S19 ribosomal protein fused to the virus non-structural protein. Genomes with this insert were selected during virus passage in cultured cells to become the predominant species, suggesting that the inserted sequence promoted virus growth. The results demonstrated that hepatitis E virus can mutate dramatically during a prolonged infection and suggests it may be important to prevent or cure chronic infections before new variants with unpredictable properties arise.
机译：戊型肝炎病毒是急性戊型肝炎的病原体，急性戊型肝炎是一种在发展中国家普遍存在的自限性疾病。对来自一名慢性感染患者的病毒基因组RNA的分子分析证实了最近的发现，即慢性感染与准类病毒的广泛多样性有关：该美国患者中某些病毒基因组的高变区包含大量连续缺失，粪便中的基因组比例很小并且血清获得了编码39个氨基酸的S19核糖体蛋白与病毒非结构蛋白融合的哺乳动物序列。在病毒传代过程中，在培养细胞中选择了带有该插入片段的基因组，使其成为主要物种，这表明插入的序列促进了病毒的生长。结果表明，戊型肝炎病毒在长时间的感染过程中会发生巨大的突变，这表明在具有无法预测的特性的新变种出现之前，预防或治愈慢性感染可能很重要。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号