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The sex ratios of probands and of secondary cases in conditions of multifactorial inheritance where liability varies with sex.

机译：在多因素继承的情况下先证者和次要案件的性别比率其中责任随性别而变化。

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摘要

Some pathological conditions affect one sex more often than the other. A curious feature of some of these conditions (dyslexia, congenital dislocation of the hip, pyloric stenosis, otosclerosis, lupus erythematosus, ankylosing spondylitis) is that the sex ratio (proportion of males) of randomly ascertained probands is more extreme than that of their affected relatives. In all these conditions, multifactorial inheritance has been suspected. A simple model is offered here of multifactorial inheritance with liability varying by sex. Under the model, such a disparity between sex ratios would be expected.

机译：一些病理状况对一种性别的影响比另一种更为常见。其中一些疾病（阅读障碍，先天性髋关节脱位，幽门狭窄，耳硬化症，红斑狼疮，强直性脊柱炎）的一个奇怪特征是，随机确定的先证者的性别比（男性比例）比其受影响者的性别比极端。亲戚们。在所有这些情况下，都怀疑有多因素继承。这里提供了一个简单的多元继承模型，其责任因性别而异。在该模型下，性别比例之间的这种差异是可以预期的。

著录项

期刊名称 Journal of Medical Genetics
作者
W H James;
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作者单位

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年(卷),期 1991(28),1
年度 1991
页码 41–43
总页数 3
原文格式 PDF
正文语种
中图分类遗传学;
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机译：在多因素继承的情况下，先证者和次要案件的性别比率，其中责任随性别而变化。

The sex ratios of probands and of secondary cases in conditions of multifactorial inheritance where liability varies with sex.

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