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首页> 美国卫生研究院文献>Journal of Neurotrauma >Impact Depth and the Interaction with Impact Speed Affect the Severity of Contusion Spinal Cord Injury in Rats
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Impact Depth and the Interaction with Impact Speed Affect the Severity of Contusion Spinal Cord Injury in Rats

机译：冲击深度和与冲击速度的相互作用影响大鼠挫伤性脊髓损伤的严重程度

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Spinal cord injury (SCI) biomechanics suggest that the mechanical factors of impact depth and speed affect the severity of contusion injury, but their interaction is not well understood. The primary aim of this work was to examine both the individual and combined effects of impact depth and speed in contusion SCI on the cervical spinal cord. Spinal cord contusions between C5 and C6 were produced in anesthetized rats at impact speeds of 8, 80, or 800 mm/s with displacements of 0.9 or 1.5 mm (n=8/group). After 7 days postinjury, rats were assessed for open-field behavior, euthanized, and spinal cords were harvested. Spinal cord tissue sections were stained for demyelination (myelin-based protein) and tissue sparing (Luxol fast blue). In parallel, a finite element model of rat spinal cord was used to examine the resulting maximum principal strain in the spinal cord during impact. Increasing impact depth from 0.9 to 1.5 mm reduced open-field scores (p<0.01) above 80 mm/s, reduced gray (GM) and white matter (WM) sparing (p<0.01), and increased the amount of demyelination (p<0.01). Increasing impact speed showed similar results at the 1.5-mm impact depth, but not the 0.9-mm impact depth. Linear correlation analysis with finite element analysis strain showed correlations (p<0.001) with nerve fiber damage in the ventral (R2=0.86) and lateral (R2=0.74) regions of the spinal cord and with WM (R2=0.90) and GM (R2=0.76) sparing. The results demonstrate that impact depth is more important in determining the severity of SCI and that threshold interactions exist between impact depth and speed.
机译：脊髓损伤（SCI）的生物力学表明，影响深度和速度的机械因素会影响挫伤的严重程度，但它们之间的相互作用尚不十分清楚。这项工作的主要目的是研究挫伤SCI对颈脊髓的冲击深度和速度的个体和综合影响。在麻醉的大鼠中，C5和C6之间的脊髓挫伤以8、80或800 / mm / s的冲击速度产生，位移为0.9或1.5 mm（n = 8 /组）。损伤后7天后，对大鼠的野外行为进行评估，安乐死，并收获脊髓。脊髓组织切片进行脱髓鞘染色（基于髓磷脂的蛋白）和组织保留染色（Luxol坚牢蓝）。平行地，使用大鼠脊髓的有限元模型来检查冲击过程中所产生的脊髓最大最大应变。将冲击深度从0.9增加到1.5 mm会降低80 mm / s以上的开阔地带得分（p <0.01），减少灰色（GM）和白质（WM）的保留（p <0.01），并增加脱髓鞘的量（p <0.01）。在1.5毫米的冲击深度下，增加的冲击速度显示出相似的结果，但在0.9毫米的冲击深度下却没有。有限元分析应变的线性相关分析显示，腹侧（R 2 = 0.86）和外侧（R 2 = 0.74）与神经纤维损伤相关（p <0.001）脊髓区域，并保留WM（R 2 = 0.90）和GM（R 2 = 0.76）。结果表明，影响深度对于确定SCI的严重程度更为重要，并且影响深度和速度之间存在阈值交互作用。

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