• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Journal of Neurotrauma >Outcome Prediction within Twelve Hours after Severe Traumatic Brain Injury by Quantitative Cerebral Blood Flow
【2h】

Outcome Prediction within Twelve Hours after Severe Traumatic Brain Injury by Quantitative Cerebral Blood Flow

机译：严重脑外伤后十二小时内通过定量脑血流预测结果

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We measured quantitative cortical mantle cerebral blood flow (CBF) by stable xenon computed tomography (CT) within the first 12 h after severe traumatic brain injury (TBI) to determine whether neurologic outcome can be predicted by CBF stratification early after injury. Stable xenon CT was used for quantitative measurement of CBF (mL/100 g/min) in 22 cortical mantle regions stratified as follows: low (0–8), intermediate (9–30), normal (31–70), and hyperemic (>70) in 120 patients suffering severe (Glasgow Coma Scale [GCS] score ≤8) TBI. For each of these CBF strata, percentages of total cortical mantle volume were calculated. Outcomes were assessed by Glasgow Outcome Scale (GOS) score at discharge (DC), and 1, 3, and 6 months after discharge. Quantitative cortical mantle CBF differentiated GOS 1 and GOS 2 (dead or vegetative state) from GOS 3–5 (severely disabled to good recovery; p<0.001). Receiver operating characteristic (ROC) curve analysis for percent total normal plus hyperemic flow volume (TNHV) predicting GOS 3–5 outcome at 6 months for CBF measured <6 and <12 h after injury showed ROC area under the curve (AUC) cut-scores of 0.92 and 0.77, respectively. In multivariate analysis, percent TNHV is an independent predictor of GOS 3–5, with an odds ratio of 1.460 per 10 percentage point increase, as is initial GCS score (OR=1.090). The binary version of the Marshall CT score was an independent predictor of 6-month outcome, whereas age was not. These results suggest that quantitative cerebral cortical CBF measured within the first 6 and 12 h after TBI predicts 6-month outcome, which may be useful in guiding patient care and identifying patients for randomized clinical trials. A larger multicenter randomized clinical trial is indicated.
机译：我们在严重外伤性脑损伤（TBI）后的前12小时内，通过稳定的氙气计算机断层扫描（CT）测量了定量的皮质套层脑血流量（CBF），以确定是否可以通过伤后早期的CBF分层预测神经系统结果。稳定的氙气CT用于定量测量22个皮质地幔区域中的CBF（mL / 100 g / min），其分层如下：低（0-8），中（9-30），正常（31-70）和充血（> 70）在120例严重（格拉斯哥昏迷量表[GCS]评分≤8）的TBI患者中。对于这些CBF层中的每一个，都计算了总的皮质套层体积百分比。出院时（DC）以及出院后1、3和6个月，通过格拉斯哥成果量表（GOS）评分评估结局。定量的皮质套层CBF可以使GOS 1和GOS 2（死或营养状态）与GOS 3-5（严重丧失，恢复良好； p <0.001）区分开来。接受者操作特征（ROC）曲线分析，显示正常总血流和充血流量（TNHV）的百分比，预测伤后<6和<12 h的CBF在6个月时的GOS 3-5结果显示曲线下的ROC面积（AUC）分别为0.92和0.77。在多变量分析中，TNHV百分比是GOS 3–5的独立预测因子，每增加10个百分点，比值比为1.460，初始GCS得分也是如此（OR = 1.090）。马歇尔CT评分的二进制版本是6个月预后的独立预测因子，而年龄则不是。这些结果表明，在TBI出现后的前6小时和12小时内测量的定量大脑皮层CBF可以预测6个月的结果，这可能有助于指导患者护理和确定患者进行随机临床试验。指出了较大的多中心随机临床试验。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号