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首页> 美国卫生研究院文献>Molecular Medicine Reports >Investigation of the neuroprotective effects of Lycium barbarum water extract in apoptotic cells and Alzheimers disease mice
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Investigation of the neuroprotective effects of Lycium barbarum water extract in apoptotic cells and Alzheimers disease mice

机译：枸杞水提取物对凋亡细胞和阿尔茨海默氏病小鼠神经保护作用的研究

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Alzheimer's disease (AD) affects people worldwide and is caused by chronic and progressive damage to the central nervous system. Lycium barbarum (LB), a renowned functional food and medicinal plant in Southeast Asia, may possess protective effects against nerve injury. The present study aimed to investigate the neuroprotective effects of LB water extract in a differentiated (D)PC12 cellular apoptosis model induced by L-glutamic acid (L-Glu), and a mouse model of AD, induced by the combination of AlCl3 and D-galactose. LB markedly increased DPC12 cell survival against L-Glu induced damage by increasing cell viability, reducing the apoptosis rate and G1 phase arrest, suppressing intracellular reactive oxygen species accumulation, blocking Ca2+ overload and preventing mitochondrial membrane potential depolarization. LB additionally normalized the expression levels of apoptosis regulator Bcl-2, apoptosis regulator BAX, and cleaved caspase-3, −8 and −9 in L-Glu exposed cells. In the AD mouse model, LB increased the amount of horizontal and vertical movement in the autonomic activity test, improved endurance time in the rotarod test and decreased escape latency time in the Morris water maze test. Additionally, the levels of acetylcholine and choline acetyltransferase were significantly increased in the serum and hypothalamus in the LB-treated AD mice. These data suggested that LB may exert neuroprotective effects and may aid in preventing neurodegenerative disease.
机译：阿尔茨海默氏病（AD）影响全世界的人，是由中枢神经系统的慢性和进行性损害引起的。枸杞（LB）是东南亚著名的功能性食品和药用植物，对神经损伤可能具有保护作用。本研究旨在研究LB水提取物在L-谷氨酸（L-Glu）诱导的分化（D）PC12细胞凋亡模型和AlCl3和D联合诱导的AD小鼠模型中的神经保护作用。 -半乳糖。 LB通过增加细胞活力，降低细胞凋亡率和G1期阻滞，抑制细胞内活性氧的积累，阻断Ca 2 + 超载并阻止线粒体膜电位，显着提高DPC12细胞对抗L-Glu诱导的损伤的存活率。去极化。 LB还可以使暴露于L-Glu的细胞中凋亡调节因子Bcl-2，凋亡调节因子BAX和裂解的caspase-3，-8和-9的表达水平正常化。在AD小鼠模型中，LB在自主神经活动测试中增加了水平和垂直移动的量，在旋转脚架测试中改善了耐力时间，并在Morris水迷宫测试中减少了逃脱潜伏时间。另外，在用LB处理的AD小鼠中，血清和下丘脑中的乙酰胆碱和胆碱乙酰转移酶的水平显着增加。这些数据表明LB可能发挥神经保护作用，并可能有助于预防神经退行性疾病。

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