...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Molecular medicine reports >Investigation of the neuroprotective effects of Lycium barbarum water extract in apoptotic cells and Alzheimer's disease mice
【24h】

Investigation of the neuroprotective effects of Lycium barbarum water extract in apoptotic cells and Alzheimer's disease mice

机译：枸杞水提取物在凋亡细胞和阿尔茨海默病小鼠中的神经保护作用研究

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Alzheimer's disease (AD) affects people worldwide and is caused by chronic and progressive damage to the central nervous system. Lycium barbarum (LB), a renowned functional food and medicinal plant in Southeast Asia, may possess protective effects against nerve injury. The present study aimed to investigate the neuroprotective effects of LB water extract in a differentiated (D)PC12 cellular apoptosis model induced by L-glutamic acid (L-Glu), and a mouse model of AD, induced by the combination of AlCl3 and D-galactose. LB markedly increased DPC12 cell survival against L-Glu induced damage by increasing cell viability, reducing the apoptosis rate and G1 phase arrest, suppressing intracellular reactive oxygen species accumulation, blocking Ca2+ overload and preventing mitochondrial membrane potential depolarization. LB additionally normalized the expression levels of apoptosis regulator Bcl-2, apoptosis regulator BAX, and cleaved caspase-3, -8 and -9 in L-Glu exposed cells. In the AD mouse model, LB increased the amount of horizontal and vertical movement in the autonomic activity test, improved endurance time in the rotarod test and decreased escape latency time in the Morris water maze test. Additionally, the levels of acetylcholine and choline acetyltransferase were significantly increased in the serum and hypothalamus in the LB-treated AD mice. These data suggested that LB may exert neuroprotective effects and may aid in preventing neurodegenerative disease.
机译：阿尔茨海默病（广告）影响全世界的人，是由慢性和渐进性损害引起的中枢神经系统。枸杞（LB）是东南亚着名的功能食品和药用植物，可对神经损伤具有保护作用。本研究旨在探讨LB谷氨酸（L-Glu）诱导的分化（D）PC12细胞凋亡模型中LB水提取物的神经保护作用，以及通过ALCL3和D组合诱导的AD的小鼠模型。 -Galaction。 LB通过提高细胞活力，降低细胞凋亡率和G1相位抑制，抑制细胞内反应性氧物质积累，阻断CA2 +过载，阻断CA2 +过载，阻断CA2 +过载和防止线粒体膜电位去极化，降低了L-Glu诱导的损伤。 LB另外归一化了凋亡调节剂Bcl-2，凋亡调节剂Bax和裂解Caspase-3，-8和-9的表达水平。在AD小鼠模型中，LB增加了自主活动测试中的水平和垂直运动的量，改善了旋转摩尔水迷宫试验中的旋转率测试中的耐久性时间并降低了逃逸潜伏期。另外，在LB处理的广告小鼠中，血清和下丘脑中乙酰胆碱和胆碱乙酰转移酶的水平显着增加。这些数据表明，LB可能发挥神经保护作用，并有助于预防神经退行性疾病。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号