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首页> 美国卫生研究院文献>Medical Physics >Monte Carlo simulations and radiation dosimetry measurements of peripherally applied HDR 192Ir breast brachytherapy D-shaped applicators
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Monte Carlo simulations and radiation dosimetry measurements of peripherally applied HDR 192Ir breast brachytherapy D-shaped applicators

机译：外围应用的HDR 192Ir乳房近距离放射D形涂抹器的蒙特卡洛模拟和辐射剂量测量

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Conformal dose coverage for accelerated partial breast irradiation or radiotherapy boost can be obtained with AccuBoost® D-shaped brachytherapy applicators using a flattened surface positioned near the patient. Three D-shaped applicators (D45∕D53∕D60) were dosimetrically characterized using Monte Carlo methods (MCNP5), air ionization chambers (Farmer and Markus), and radiochromic film (GafChromic EBT) in polystyrene and ICRU 44 breast tissue. HDR 192Ir source dwell times were either constant or optimized to improve skin dose uniformity. Scatter dose decreased as depth decreased. 10 mm beyond the applicator aperture, dose reductions of 90% and 51% were observed at depths of 0 and 30 mm, respectively. Similarly, planar dose uniformity improved as depth decreased and was also due to scatter and applicator geometry. Dose uniformity inside the applicator aperture was approximately 11% and 15% for all three applicators at the skin and 30 mm deep, respectively. Depth dose measurements in polystyrene using ion chamber and radiochromic film agreed with Monte Carlo results within 2%. Discrepancies between film and Monte Carlo dose profiles at 30 mm depth were within 1%.
机译：可以使用AccuBoost ® D形近距离放射治疗器使用靠近患者的平坦表面来获得用于加速局部乳房照射或放射治疗加速的保形剂量范围。使用蒙特卡洛方法（MCNP5），空气电离室（Farmer和Markus）以及聚苯乙烯和ICRU 44乳腺组织中的放射致变色薄膜（GafChromic EBT）对三个D形施加器（D45 ∕ D53 ∕ D60）进行剂量测定。 HDR 192 Ir源停留时间是恒定的或经过优化可提高皮肤剂量均匀性。散射剂量随深度减小而减小。在距涂抹器孔口10毫米处，在0毫米和30毫米深度处分别观察到90％和51％的剂量减少。类似地，平面剂量均匀性随深度的减小而提高，这也归因于散射和施加器的几何形状。对于所有三个在皮肤和30 mm深处的涂抹器，涂抹器孔内的剂量均匀度分别约为11％和15％。使用离子室和放射致变色膜在聚苯乙烯中进行的深度剂量测量与Monte Carlo结果一致，误差在2％以内。在30毫米深度处，胶片和蒙特卡洛剂量分布之间的差异在1％以内。

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