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首页> 美国卫生研究院文献>Oncology Letters >Dosimetric comparison of intensity-modulated radiation therapy and volumetric-modulated arc therapy plans for the treatment of glioma using flattening filter-free and flattening filter modes
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Dosimetric comparison of intensity-modulated radiation therapy and volumetric-modulated arc therapy plans for the treatment of glioma using flattening filter-free and flattening filter modes

机译：使用无展平过滤器和展平过滤器模式对胶质瘤治疗的强度调制放射治疗和体积调制电弧治疗计划的剂量学比较

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摘要

In the present study, the dose verification between 6X and 6X flattening filter-free (FFF) in intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) was compared, and the advantages and disadvantages of different radiotherapy plans were evaluated. All four plans achieved comparable heterogeneity and conformity indices. For frontal tumor, VMAT demonstrated more improved sparing of the brainstem compared with the IMRT (P=0.045); while in the model of FFF, the Dmax of eye lens was significantly reduced by 16–21% (P<0.001). The organs at risk (OARs) in the temporal lobe tumor were spared well in the IMRT plan. With the removal of FF, the low-dose volume for both tumor locations was significantly reduced (P<0.05). By contrast, there was no significant difference in monitor units (MUs) with FFF, but the MUs were significantly reduced in the VMAT plan (P<0.001). Regarding the protection of OARs, FFF appeared to be superior compared with FF. For the frontal glioma, the VMAT plan had more advantages, and for temporal lobe tumor, dynamic IMRT was more appropriate. The VMAT plan reduces the low-dose volume of normal brain tissues and the MUs. While the removal of FF may increase the dose rate, the shortened treatment delivery time may improve the accuracy of treatment due to intra-fractional patient motion.
机译：在本研究中，比较了强度调制放射治疗（IMRT）和容积调制弧光治疗（VMAT）中的6X和6X扁平化无过滤器（FFF）之间的剂量验证，并评估了不同放疗计划的优缺点。这四个计划均实现了可比的异质性和合格指数。对于额部肿瘤，与IMRT相比，VMAT表现出更好的脑干保留（P = 0.045）；而在FFF模型中，眼镜片的Dmax显着降低了16–21％（P <0.001）。 IMRT计划很好地保留了颞叶肿瘤中的高危器官（OAR）。随着FF的去除，两个肿瘤位置的低剂量体积显着降低（P <0.05）。相比之下，具有FFF的监护仪单元（MU）没有显着差异，但VMAT计划中的MU显着减少（P <0.001）。关于OAR的保护，FFF似乎比FF好。对于额神经胶质瘤，VMAT计划具有更多优势，而对于颞叶肿瘤，动态IMRT更合适。 VMAT计划可减少正常脑组织和MU的低剂量体积。尽管FF的去除可以增加剂量率，但是由于患者内部运动，缩短的治疗递送时间可以提高治疗的准确性。

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