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首页> 美国卫生研究院文献>Scientific Reports >Evidence of large genetic influences on dog ownership in the Swedish Twin Registry has implications for understanding domestication and health associations
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Evidence of large genetic influences on dog ownership in the Swedish Twin Registry has implications for understanding domestication and health associations

机译：瑞典双胞胎登记处对狗的拥有大量遗传影响的证据对理解驯养和健康协会具有影响

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Dogs were the first domesticated animal and, according to the archaeological evidence, have had a close relationship with humans for at least 15,000 years. Today, dogs are common pets in our society and have been linked to increased well-being and improved health outcomes in their owners. A dog in the family during childhood is associated with ownership in adult life. The underlying factors behind this association could be related to experiences or to genetic influences. We aimed to investigate the heritability of dog ownership in a large twin sample including all twins in the Swedish Twin Registry born between 1926 and 1996 and alive in 2006. Information about dog ownership was available from 2001 to 2016 from national dog registers. The final data set included 85,542 twins from 50,507 twin pairs with known zygosity, where information on both twins were available in 35,035 pairs. Structural equation modeling was performed to estimate additive genetic effects (the heritability), common/shared environmental, and uniqueon-shared environmental effects. We found that additive genetic factors largely contributed to dog ownership, with heritability estimated at 57% for females and 51% for males. An effect of shared environmental factors was only observed in early adulthood. In conclusion, we show a strong genetic contribution to dog ownership in adulthood in a large twin study. We see two main implications of this finding: (1) genetic variation may have contributed to our ability to domesticate dogs and other animals and (2) potential pleiotropic effects of genetic variation affecting dog ownership should be considered in studies examining health impacts of dog ownership.
机译：狗是第一只被驯化的动物，根据考古证据，狗与人至少有15,000年的亲密关系。如今，狗已经成为我们社会中的常见宠物，并与主人的福祉和健康状况改善息息相关。童年时期家庭中的狗与成年后的拥有权有关。这种关联背后的潜在因素可能与经验或遗传影响有关。我们旨在调查一个大型双胞胎样本中狗主人的遗传力，包括出生于1926年至1996年，2006年还活着的瑞典双胞胎登记处的所有双胞胎。有关狗主人的信息可从2001年至2016年从全国狗登记簿中获得。最终数据集包括来自50507对具有已知接合性的双胞胎中的85542对双胞胎，其中关于双胞胎的信息可在35035对中获得。进行了结构方程建模，以估算附加的遗传效应（遗传力），共同/共有的环境和独特/非共有的环境效应。我们发现，附加的遗传因素在很大程度上促进了狗的拥有，雌性的遗传力估计为57％，雄性为51％。仅在成年早期观察到共享环境因素的影响。总之，在一项大型的双胞胎研究中，我们显示了成年犬拥有强遗传因素。我们发现这一发现有两个主要含义：（1）遗传变异可能有助于我们驯养狗和其他动物；（2）研究犬所有权对健康的影响的研究中应考虑遗传变异影响犬所有权的潜在多效效应。

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