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首页> 美国卫生研究院文献>SpringerPlus >Comparison of dose distributions hippocampus in high grade gliomas irradiation with linac-based imrt and volumetric arc therapy: a dosimetric study
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Comparison of dose distributions hippocampus in high grade gliomas irradiation with linac-based imrt and volumetric arc therapy: a dosimetric study

机译：基于直线加速器的imrt和容积弧光疗法在高级别胶质瘤照射中海马剂量分布的比较：剂量学研究

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摘要

The aim of this study was to assess the feasibility of sparing contralateral hippocampus during partial brain radiotherapy in high grade gliomas. 20 previously treated patients were replanned to 60 Gy in 30 fractions with sparing intensity-modulated radiotherapy (IMRT) and volumetric modulated arctherapy (VMAT) using the following planning objectives: 100 % of PTV covered by 95% isodose without violating organs at risk (OAR) and hot spot dose constraints. For each, standard intensity-modulated radiotherapy (IMRT) plans were generated, as well as sparing IMRT and VMAT plans which spared contralateral (hemispheric cases) hippocampus. When the three plans were compared, there was equivalent PTV coverage, homogeneity, and conformality. Sparing IMRT significantly reduced maximum, mean, V20, V30 and V40 hippocampus doses compared with standart IMRT and VMAT (p < 0.05). VMAT significantly reduced maximum left lens and mean eye doses compared with standart IMRT and sparing IMRT (p < 0.05). Brainstem, chiasm, left and right optic nerves, right eyes and lens doses were similar. VMAT significantly reduced monitor units compared with standart IMRT and sparing IMRT (p < 0.05). It is possible to spare contralateral hippocampus during PBRT for high grade gliomas using IMRT. This approach may reduce late cognitive sequelae of cranial radiotherapy.
机译：本研究的目的是评估在高级脑胶质瘤部分脑放疗期间保留对侧海马的可行性。使用以下计划目标，将20例先前接受治疗的患者分30次，重新规划为60 Gy，采用保守的强度调制放疗（IMRT）和体积调制弧光疗法（VMAT）：100％的PTV被95％的等剂量药物覆盖而没有侵犯危险器官（OAR） ）和热点剂量限制。对于每一个，都生成了标准的强度调制放射治疗（IMRT）计划，并保留了IMRT和VMAT计划，这些计划避免了对侧（半球形病例）海马体。比较这三个计划时，PTV的覆盖范围，同质性和共形性相当。与标准IMRT和VMAT相比，节省IMRT可以显着降低海马最大，平均，V20，V30和V40剂量（p <0.05）。与标准IMRT和备用IMRT相比，VMAT显着降低了最大左眼镜片和平均眼部剂量（p <0.05）。脑干，前交叉，左右视神经，右眼和晶状体剂量相似。与标准IMRT和节省IMRT相比，VMAT显着减少了监视单元（p <0.05）。使用IMRT可以在PBRT期间为高水平的神经胶质瘤保留对侧海马。这种方法可以减少颅脑放疗的晚期认知后遗症。

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