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首页> 美国卫生研究院文献>Scientific Reports >Association between Open-Angle Glaucoma and the Risks of Alzheimer’s and Parkinson’s Diseases in South Korea: A 10-year Nationwide Cohort Study
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Association between Open-Angle Glaucoma and the Risks of Alzheimer’s and Parkinson’s Diseases in South Korea: A 10-year Nationwide Cohort Study

机译：开角型青光眼与韩国阿尔茨海默氏病和帕金森氏病风险之间的关联：一项为期10年的全国性队列研究

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摘要

We aimed to investigate the risks of Alzheimer’s (AD) and Parkinson’s disease (PD) in the 10 years following diagnosis of open-angle glaucoma (OAG) using a nationwide cohort. This propensity score-matched retrospective cohort study included 1,025,340 subjects from the Korean National Health Insurance Service National Sample Cohort database. The OAG group (n = 1,469) included patients who were initially diagnosed with OAG between 2004 and 2007, and the subjects in the comparison group were matched in a 1:5 ratio using propensity scores. Cox regression analyses were performed to investigate the risks of developing AD or PD. The diagnosis of OAG was significantly associated with an increased incidence of AD (hazard ratio [HR] = 1.403, 95% confidence interval [CI] 1.180–1.669, p < 0.001), but not PD (HR = 0.995, 95% CI 0.620–1.595, p = 0.983) after adjusting for possible confounding factors. In subgroup analyses, participants with OAG aged ≥65 years were more likely to develop AD compared with those aged <65 years, and female OAG patients had a greater risk of developing AD than males. Patients diagnosed with OAG have a higher risk of developing AD, but not PD, and the risk differed according to age and sex.
机译：我们的目标是使用全国性队列研究调查开角型青光眼（OAG）诊断后的10年内，阿尔茨海默氏病（AD）和帕金森氏病（PD）的风险。这项倾向得分匹配的回顾性队列研究包括了来自韩国国民健康保险服务全国样本队列数据库的1,025,340名受试者。 OAG组（n = 1,469）包括最初在2004年至2007年间被诊断出患有OAG的患者，比较组的受试者使用倾向评分以1：5的比例进行匹配。进行了Cox回归分析以调查发生AD或PD的风险。 OAG的诊断与AD发生率显着增加相关（危险比[HR] = 1.403，95％置信区间[CI] 1.180-1.669，p <0.001），而不是PD（HR = 0.995，95％CI 0.620） –1.595，p = 0.983），然后调整可能的混杂因素。在亚组分析中，与年龄小于65岁的OAG相比，年龄≥65岁的OAG参与者更容易发生AD，女性OAG病人的发生AD的风险也比男性高。被诊断为OAG的患者发生AD的风险更高，但PD则更高，并且该风险因年龄和性别而异。

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