Prolonged Toxicity after Amitriptyline Overdose in a Patient Deficient in CYP2D6 Activity

机译：CYP2D6活性不足的患者服用阿米替林过量后的长期毒性

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IntroductionAmitriptyline and its metabolite, nortriptyline, are metabolized, in part, by CYP2D6, a polymorphic enzyme. About 8% of Caucasians are deficient in CYP2D6 activity.

机译：简介阿米替林及其代谢物去甲替林被多态性酶CYP2D6部分代谢。约8％的白种人缺乏CYP2D6活性。

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期刊名称 Journal of Medical Toxicology
作者
Jennifer Cohen Smith; Steven C. Curry;
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作者单位

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年(卷),期 2011(7),3
年度 2011
页码 220–223
总页数 4
原文格式 PDF
正文语种
中图分类毒物学（毒理学）;
关键词
Amitriptyline Toxicokinetics Pharmacokinetics CYP2D6 Overdose;

机译：阿米替林;毒物动力学;药代动力学;CYP2D6;过量;

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专利

1. Prolonged Toxicity after Amitriptyline Overdose in a Patient Deficient in CYP2D6 Activity [J] . Jennifer Cohen Smith, Steven C. Curry Journal of Medical Toxicology . 2011,第3期

机译：CYP2D6活性不足的患者服用阿米替林过量后的长期毒性
2. Prolonged toxicity from amphetamine and quetiapine following overdose in a patient also taking cobicistat [J] . Roberts Darren M., Othman Jad, Dawson Andrew H. Clinical toxicology: the official journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists . 2017,第5期

机译：在患者服用COBICISTAT的患者中过量后，从AMphetamine和Quetiapine的长期毒性
3. Adverse drug interaction between risperidone and carbamazepine in a patient with chronic schizophrenia and deficient CYP2D6 activity. [J] . Spina E, Scordo MG, Avenoso A, Journal of clinical psychopharmacology . 2001,第1期

机译：利培酮和卡马西平在慢性精神分裂症和CYP2D6活性不足患者中的不良药物相互作用。
4. Association of CYP2D6 and ADRB1 Single Nucleotide Polymorphisms and Response to Beta Blocker Therapy in a Patient Sample Set with Cardiovascular Diseases from Romania [C] . Andrada Camelia Guta, Liana Gabriela Gruescu Molecular Medicine TRI-CON. . 2014

机译：CYP2D6和ADRB1单核苷酸多态性和对患者样本中β受体疗法的响应与来自罗马尼亚的心血管疾病
5. The regulation of glutamate transmission in the substantia nigra: Implications for methamphetamine (METH) toxicity and overdose management [D] . Hatzipetros, Theodoulos 2007

机译：黑质中谷氨酸传递的调节：对甲基苯丙胺（METH）毒性和药物过量管理的影响
6. Tamoxifen Dose Escalation in Patients With Diminished CYP2D6 Activity Normalizes Endoxifen Concentrations Without Increasing Toxicity [O] . Daniel L. Hertz, Allison Deal, Joseph G. Ibrahim, 2016

机译：CYP2D6活性降低的患者中他莫昔芬的剂量递增可正常化内多昔芬的浓度而不增加毒性
7. Tamoxifen Dose Escalation in Patients With Diminished CYP2D6 Activity Normalizes Endoxifen Concentrations Without Increasing Toxicity [O] . Hertz, Daniel L., Deal, Allison, Ibrahim, Joseph G., 2016

机译：CYp2D6活性降低患者的他莫昔芬剂量升级使内毒素浓度正常化而不增加毒性

Prolonged Toxicity after Amitriptyline Overdose in a Patient Deficient in CYP2D6 Activity

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