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首页> 美国卫生研究院文献>Scientific Reports >Reduced White Matter Integrity in Antisocial Personality Disorder: A Diffusion Tensor Imaging Study
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Reduced White Matter Integrity in Antisocial Personality Disorder: A Diffusion Tensor Imaging Study

机译：反社会人格障碍中白质完整性的降低：扩散张量成像研究

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Emerging neuroimaging research suggests that antisocial personality disorder (ASPD) may be linked to abnormal brain anatomy, but little is known about possible impairments of white matter microstructure in ASPD, as well as their relationship with impulsivity or risky behaviors. In this study, we systematically investigated white matter abnormalities of ASPD using diffusion tensor imaging (DTI) measures: fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD). Then, we further investigated their correlations with the scores of impulsivity or risky behaviors. ASPD patients showed decreased FA in multiple major white matter fiber bundles, which connect the fronto-parietal control network and the fronto-temporal network. We also found AD/RD deficits in some additional white matter tracts that were not detected by FA. More interestingly, several regions were found correlated with impulsivity or risky behaviors in AD and RD values, although not in FA values, including the splenium of corpus callosum, left posterior corona radiate/posterior thalamic radiate, right superior longitudinal fasciculus, and left inferior longitudinal fasciculus. These regions can be the potential biomarkers, which would be of great interest in further understanding the pathomechanism of ASPD.
机译：新兴的神经影像学研究表明，反社会人格障碍（ASPD）可能与异常的大脑解剖结构有关，但对ASPD中白质微观结构的可能损害及其与冲动或危险行为的关系知之甚少。在这项研究中，我们使用扩散张量成像（DTI）措施系统地研究了ASPD的白质异常：分数各向异性（FA），轴向扩散率（AD）和径向扩散率（RD）。然后，我们进一步研究了它们与冲动或危险行为得分的相关性。 ASPD患者在连接额顶控制网络和额颞网络的多个主要白质纤维束中显示出FA降低。我们还发现了FA未能检测到的其他一些白质区域的AD / RD缺陷。更有趣的是，发现了几个区域与AD和RD值的冲动性或危险行为相关，尽管与FA值无关，包括call体的脾脏，左电晕放射/丘脑后放射，右上纵筋膜和左下纵肌fasciculus。这些区域可能是潜在的生物标志物，将对进一步了解ASPD的发病机理非常感兴趣。

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