...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Scientific reports. >Reduced White Matter Integrity in Antisocial Personality Disorder: A Diffusion Tensor Imaging Study
【24h】

Reduced White Matter Integrity in Antisocial Personality Disorder: A Diffusion Tensor Imaging Study

机译：减少反社会人格障碍的白质完整性：扩散张量成像研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Emerging neuroimaging research suggests that antisocial personality disorder (ASPD) may be linked to abnormal brain anatomy, but little is known about possible impairments of white matter microstructure in ASPD, as well as their relationship with impulsivity or risky behaviors. In this study, we systematically investigated white matter abnormalities of ASPD using diffusion tensor imaging (DTI) measures: fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD). Then, we further investigated their correlations with the scores of impulsivity or risky behaviors. ASPD patients showed decreased FA in multiple major white matter fiber bundles, which connect the fronto-parietal control network and the fronto-temporal network. We also found AD/RD deficits in some additional white matter tracts that were not detected by FA. More interestingly, several regions were found correlated with impulsivity or risky behaviors in AD and RD values, although not in FA values, including the splenium of corpus callosum, left posterior corona radiate/posterior thalamic radiate, right superior longitudinal fasciculus, and left inferior longitudinal fasciculus. These regions can be the potential biomarkers, which would be of great interest in further understanding the pathomechanism of ASPD.
机译：新兴的神经影像学研究表明，反社会人格障碍（ASPD）可能与异常脑解剖学相关联，但是关于白质微观结构在ASPD中可能的损伤，以及它们与冲动或冒险行为的关系。在这项研究中，我们使用扩散张量成像（DTI）测量系统地研究了ASPD的白质异常：分数各向异性（FA），轴向扩散率（AD）和径向扩散率（RD）。然后，我们进一步调查了与冲动或冒险行为的分数的相关性。 aspd患者在多个主要白质纤维束中显示出较低的FA，该纤维捆绑在额外的控制网络和翻版网络中连接。我们还在FA未检测到的一些额外的白质子中找到了AD / RD缺陷。更有趣的是，若干地区被发现与AD和RD值中的冲动或冒险行为相关，尽管不参加Corpus Callosum的脾脏，但留下后电晕辐射/后丘脑辐射，右较高的纵向束，左下纵向束拟合。这些地区可以是潜在的生物标志物，这对进一步了解ASPD的土地机制是非常兴趣的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号