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Magnesium alloy covered stent for treatment of a lateral aneurysm model in rabbit common carotid artery: An in vivo study

机译:镁合金包覆支架治疗兔颈总动脉外侧动脉瘤模型的体内研究

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摘要

Magnesium alloy covered stents have rarely been used in the common carotid artery (CCA). We evaluated the long-term efficacy of magnesium alloy covered stents in a lateral aneurysm model in rabbit CCA. Magnesium alloy covered stents (group A, n = 7) or Willis covered stents (group B, n = 5) were inserted in 12 New Zealand White rabbits and they were followed up for 12 months. The long-term feasibility for aneurysm occlusion was studied through angiograms; the changes in vessel area and lumen area were assessed with IVUS. Complete aneurysmal occlusion was achieved in all aneurysms. Angiography showed that the diameter of the stented CCA in group A at 6 and 12 months was significantly greater than the diameter immediately after stent placement. On intravascular ultrasound (IVUS) examination, the mean lumen area of the stented CCA in group A was significantly greater at 6 and 12 months than that immediately after stent placement; the mean lumen area was also significantly greater in group A than in group B at the same time points. The magnesium alloy covered stents proved to be an effective approach for occlusion of lateral aneurysm in the rabbit CCA; it provides distinct advantages that are comparable to that obtained with the Willis covered stent.
机译:镁合金覆盖的支架很少用于颈总动脉(CCA)。我们评估了兔CCA侧动脉瘤模型中镁合金覆盖支架的长期疗效。将镁合金覆膜支架(A组,n = 7)或Willis覆膜支架(B,n = 5)插入12只新西兰白兔中,并随访12个月。通过血管造影术研究了动脉瘤闭塞的长期可行性。用IVUS评估血管面积和管腔面积的变化。所有动脉瘤均实现了完全的动脉瘤闭塞。血管造影显示,在第6和12个月时,A组的CCA支架直径明显大于支架放置后的直径。经血管内超声(IVUS)检查,A组在第6和12个月时,CCA支架的平均管腔面积明显大于支架置入后的平均管腔面积。在同一时间点,A组的平均管腔面积也显着大于B组。镁合金覆膜支架被证明是阻塞兔CCA侧动脉瘤的有效方法。它提供的独特优势可与Willis覆膜支架获得的优势相媲美。

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