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首页> 美国卫生研究院文献>Scientific Reports >Chronic kidney disease is associated with a higher 90-day mortality than other chronic medical conditions in patients with sepsis
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Chronic kidney disease is associated with a higher 90-day mortality than other chronic medical conditions in patients with sepsis

机译：与败血症患者的其他慢性医学状况相比慢性肾脏病具有更高的90天死亡率

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According to previous studies, the clinical course of sepsis could be affected by preexisting medical conditions, which are very common among patients with sepsis. This observational study aimed at investigating whether common chronic medical conditions affect the 90-day mortality risk in adult Caucasian patients with sepsis. A total of 482 patients with sepsis were enrolled in this study. The ninety-day mortality was the primary outcome; organ failure was the secondary outcome. Sepsis-related organ failure assessment (SOFA) scores and the requirements for organ support were evaluated to assess organ failure. A multivariate Cox regression model for the association between the 90-day mortality risk and chronic preexisting medical conditions adjusted for all relevant confounders and mortality predictors revealed the highest hazard ratio for patients with chronic kidney disease (CKD) (hazard ratio, 2.25; 95% CI, 1.46-3.46; p = 0.0002). Patients with CKD had higher SOFA scores than patients without CKD (8.9 ± 4.0 and 6.5 ± 3.4, respectively; p < 0.0001). Additionally, an analysis of organ-specific SOFA scores revealed higher scores in three organ systems (kidney, cardiovascular and coagulation). Patients with CKD have the highest 90-day mortality risk compared with patients without CKD or with other chronic medical conditions.
机译：根据以前的研究，败血症的临床病程可能会受到先前存在的医学状况的影响，这在败血症患者中非常普遍。这项观察性研究旨在调查常见的慢性医学状况是否会影响成年白种人败血症患者的90天死亡风险。本研究共招募了482名败血症患者。 90天的死亡率是主要结果；器官衰竭是次要结果。评估败血症相关器官衰竭评估（SOFA）分数和器官支持要求，以评估器官衰竭。针对所有相关混杂因素和死亡率预测因素进行调整的90天死亡风险与慢性既往疾病之间的关联的多变量Cox回归模型显示，慢性肾脏病（CKD）患者的最高危险比（危险比为2.25； 95％ CI，1.46-3.46； p ＝ 0.0002）。 CKD患者的SOFA评分高于无CKD的患者（分别为8.9±4.0和6.5±3.4； p <0.0001）。此外，对器官特异性SOFA得分的分析显示，在三个器官系统（肾脏，心血管和凝血）中得分更高。与没有CKD或其他慢性病的患者相比，患有CKD的患者的90天死亡风险最高。

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