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Predicting Subtypes of Thymic Epithelial Tumors Using CT: New Perspective based on a Comprehensive Analysis of 216 Patients

机译:利用CT预测胸腺上皮肿瘤的亚型:基于对216例患者的综合分析的新视角

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摘要

It is highly necessary to identify low versus high risk thymic epithelial tumors (TETs) before operation to guide optimal treatment strategies. Current CT diagnostic parameters could not effectively achieve this goal. We evaluated three parameters of CT scan in a cohort of 216 TETs patients. Parameters of contrast enhancement, risk of aggressiveness, and nodule with fibrous septum were evaluated in low (A, AB) versus high risk (B1, B2, B3 and thymic carcinoma) TETs. Grade of contrast enhancement showed predictive value in classifying low and high risk TETs well. A maximal contrast-enhanced range of 25.5 HU could produce 78.8% sensitivity and 68.5% specificity in determining low risk subtypes. Additionally, risk of aggressiveness parameter was demonstrated to be associated with TETs subtype (r = 0.801, P < 0.001) and may add confidence in determining low versus high risk subtypes. Furthermore, multiple nodule with fibrous septum could suggest subtype AB. Findings from this study support role of studied parameters of CT manifestations in predicting the low and high risk stages of TETs. These findings provide empirical evidence for incorporating these parameters in clinical practice for identifying TETs stage before operation, if validated in additional studies.
机译:术前确定低风险和高风险的胸腺上皮肿瘤(TET)十分必要,以指导最佳治疗策略。当前的CT诊断参数无法有效地实现这一目标。我们评估了216名TET患者的CT扫描的三个参数。在低(A,AB)与高风险(B1,B2,B3和胸腺癌)TET中评估对比增强,侵略性风险和纤维间隔结节的参数。对比增强等级显示出对低风险和高风险TET进行良好分类的预测价值。在确定低风险亚型时,最大的对比度增强范围为25.5 HU可以产生78.8%的敏感性和68.5%的特异性。此外,攻击性风险参数已证明与TETs亚型相关(r = 0.801,P <0.001),并可能增加确定低风险和高风险亚型的信心。此外,多发性结节伴纤维间隔可提示AB型。这项研究的发现支持所研究的CT表现参数在预测TET的低风险和高风险阶段中的作用。这些发现提供了将这些参数纳入临床实践的经验证据,如果在其他研究中得到验证,则可以在手术前确定TET阶段。

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