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首页> 美国卫生研究院文献>Scientific Reports >Nomogram based on albumin and neutrophil-to-lymphocyte ratio for predicting the prognosis of patients with oral cavity squamous cell carcinoma
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Nomogram based on albumin and neutrophil-to-lymphocyte ratio for predicting the prognosis of patients with oral cavity squamous cell carcinoma

机译：基于白蛋白和中性粒细胞与淋巴细胞比值的Nomogram预测口腔鳞状细胞癌患者的预后

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Increasing evidence indicates that inflammation plays a crucial role in cancer development. A novel scoring system based on albumin and the neutrophil-to-lymphocyte ratio (NLR) was developed and incorporated into a nomogram to create a more accurate prognostic tool for oral cavity squamous cell carcinoma (OSCC) patients. A retrospective review was performed on 613 consecutive patients undergoing ablative surgery for OSCC between September 2005 and December 2014. NLR and albumin were determined and used to calculate an albumin/NLR score (ANS). The nomogram was based on the ANS and several clinicopathological manifestations, and its accuracy was determined by the concordance index (c-index). A high ANS was significantly associated with aggressive tumor behaviors, such as T status, overall stage, extranodal extension, perineural invasion, tumor depth, and decreased overall survival (OS). Multivariate analysis indicated that age, overall stage, extranodal extension, and ANS were independent factors for OS. The c-index for OS prognosis was 0.750 using this nomogram compared to 0.688 using TNM staging alone. The prognostic accuracy for OS in OSCC patients can be significantly improved using a nomogram that incorporates the novel ANS and other clinicopathological variables.
机译：越来越多的证据表明炎症在癌症发展中起着至关重要的作用。开发了一种基于白蛋白和嗜中性白细胞与淋巴细胞比率（NLR）的新型评分系统，并将其纳入诺模图以创建口腔鳞状细胞癌（OSCC）患者更准确的预后工具。在2005年9月至2014年12月之间，对613例接受OSCC消融手术的连续患者进行了回顾性研究。确定了NLR和白蛋白，并用于计算白蛋白/ NLR评分（ANS）。诺模图基于ANS和几种临床病理表现，其准确性由一致性指数（c-index）决定。较高的ANS与侵袭性肿瘤行为显着相关，例如T状态，总体分期，结外扩展，神经周围浸润，肿瘤深度和总生存期（OS）降低。多因素分析表明年龄，总体阶段，结外扩展和ANS是OS的独立因素。使用该诺模图的OS预后的c指数为0.750，而单独使用TNM分期的c指数为0.688。使用包含新的ANS和其他临床病理变量的列线图，可以显着提高OSCC患者OS的预后准确性。

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