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首页> 美国卫生研究院文献>Scientific Reports >Global transcriptomic analysis suggests carbon dioxide as an environmental stressor in spaceflight: A systems biology GeneLab case study
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Global transcriptomic analysis suggests carbon dioxide as an environmental stressor in spaceflight: A systems biology GeneLab case study

机译：全球转录组学分析表明二氧化碳是航天飞行中的环境压力源：系统生物学GeneLab案例研究

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Spaceflight introduces a combination of environmental stressors, including microgravity, ionizing radiation, changes in diet and altered atmospheric gas composition. In order to understand the impact of each environmental component on astronauts it is important to investigate potential influences in isolation. Rodent spaceflight experiments involve both standard vivarium cages and animal enclosure modules (AEMs), which are cages used to house rodents in spaceflight. Ground control AEMs are engineered to match the spaceflight environment. There are limited studies examining the biological response invariably due to the configuration of AEM and vivarium housing. To investigate the innate global transcriptomic patterns of rodents housed in spaceflight-matched AEM compared to standard vivarium cages we utilized publicly available data from the NASA GeneLab repository. Using a systems biology approach, we observed that AEM housing was associated with significant transcriptomic differences, including reduced metabolism, altered immune responses, and activation of possible tumorigenic pathways. Although we did not perform any functional studies, our findings revealed a mild hypoxic phenotype in AEM, possibly due to atmospheric carbon dioxide that was increased to match conditions in spaceflight. Our investigation illustrates the process of generating new hypotheses and informing future experimental research by repurposing multiple space-flown datasets.
机译：太空飞行引入了一系列环境压力源，包括微重力，电离辐射，饮食变化和大气气体成分变化。为了了解每个环境成分对宇航员的影响，重要的是要单独研究潜在的影响。啮齿动物的航天实验涉及标准的动物饲养笼和动物围栏模块（AEM），它们是用于在航天中容纳啮齿动物的笼子。地面控制AEM设计为与航天环境相匹配。由于AEM和玻璃容器的结构，很少有研究总是检查生物学反应。为了调查与标准活体鸟笼相比，与航天器匹配的AEM中所容纳的啮齿动物的先天全球转录组模式，我们利用了来自NASA GeneLab信息库的公开数据。使用系统生物学方法，我们观察到AEM外壳与显着的转录组差异有关，包括代谢减少，免疫应答改变和可能的致瘤途径激活。尽管我们没有进行任何功能研究，但我们的发现显示出AEM中存在轻度缺氧表型，这可能是由于大气中的二氧化碳增加以匹配太空飞行条件所致。我们的研究通过重新利用多个空间数据集来说明生成新假设并为未来的实验研究提供信息的过程。

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