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首页> 美国卫生研究院文献>Scientific Reports >Azole-resistant Aspergillus fumigatus harboring TR34/L98H TR46/Y121F/T289A and TR53 mutations related to flower fields in Colombia
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Azole-resistant Aspergillus fumigatus harboring TR34/L98H TR46/Y121F/T289A and TR53 mutations related to flower fields in Colombia

机译：携带与花田相关的哥伦比亚TR34 / L98HTR46 / Y121F / T289A和TR53突变的耐偶氮烟曲霉

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Resistance to triazoles in Aspergillus fumigatus has been reported in azole-naive patients in Europe, Asia, Australia and North America. This resistance has been linked to fungicide-driven mutations in the cyp51A gene and its promoter region. We investigated the presence of environmental azole-resistant A. fumigatus strains related to the use of azole fungicides in Colombia. Soil samples were collected from flower beds, flower fields and public gardens from the outskirts, suburbs and city centre of Bogotá. Out of the 86 soil samples taken, 17 (19.8%) grew A. fumigatus of whom eight (9.3%) contained 40 strains able to grow on azole-containing itraconazole and/or voriconazole supplemented media. All but one triazole-resistant strains were isolated from soil samples collected from flower fields and flower beds (39/40). Importantly, the majority had the TR46/Y121F/T289A, TR34/L98H, and TR53 molecular resistance mechanisms and one azole resistant strain had a wild-type cyp51A gene. Soil samples from flower fields and beds contained 4 azole fungicides (penconazole, difenoconazole, tetraconazole and tebuconazole) above the limit of detection. Our findings underline the need for extensive investigations to determine azole-resistant A. fumigatus prevalence in both clinical and environmental samples in other regions of Latin America.
机译：在欧洲，亚洲，澳大利亚和北美，未使用过唑类药物的患者中，已有报道称烟曲霉对三唑类药物具有抗药性。这种耐药性与cyp51A基因及其启动子区域中的杀菌剂驱动的突变有关。我们调查了与在哥伦比亚使用唑类杀真菌剂有关的环境中对唑类具有抗性的A. fumigatus菌株。从波哥大郊区，郊区和市中心的花坛，花田和公共花园收集土壤样品。在所采集的86个土壤样品中，有17种（19.8％）烟曲霉生长，其中8种（9.3％）含有40种能够在含唑的伊曲康唑和/或伏立康唑补充培养基上生长的菌株。从花田和花坛收集的土壤样品中分离出除一种对三唑耐药的菌株（39/40）。重要的是，大多数具有TR46 / Y121F / T289A，TR34 / L98H和TR53的分子耐药机制，并且一个对唑类耐药的菌株具有野生型cyp51A基因。来自花田和花坛的土壤样品中含有超过检出限的4种唑类杀菌剂（苯康唑，苯非康唑，丁康唑和戊唑醇）。我们的发现强调需要进行广泛的调查以确定拉丁美洲其他地区的临床和环境样品中的耐唑类烟曲霉流行率。

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