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首页> 美国卫生研究院文献>Scientific Reports >Main Effects of Diagnoses Brain Regions and their Interaction Effects for Cerebral Metabolites in Bipolar and Unipolar Depressive Disorders
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Main Effects of Diagnoses Brain Regions and their Interaction Effects for Cerebral Metabolites in Bipolar and Unipolar Depressive Disorders

机译：对双相性和单相性抑郁症的脑代谢产物的诊断脑区及其相互作用的主要影响

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Previous studies suggested patients with bipolar depressive disorder (BDd) or unipolar depressive disorder (UDd) have cerebral metabolites abnormalities. These abnormalities may stem from multiple sub-regions of gray matter in brain regions. Thirteen BDd patients, 20 UDd patients and 20 healthy controls (HC) were enrolled to investigate these abnormalities. Absolute concentrations of 5 cerebral metabolites (glutamate-glutamine (Glx), N-acetylaspartate (NAA), choline (Cho), myo-inositol (mI), creatine (Cr), parietal cortex (PC)) were measured from 4 subregions (the medial frontal cortex (mPFC), anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), and parietal cortex (PC)) of gray matter. Main and interaction effects of cerebral metabolites across subregions of gray matter were evaluated. For example, the Glx was significantly higher in BDd compared with UDd, and so on. As the interaction analyses showed, some interaction effects existed. The concentrations of BDds’ Glx, Cho, Cr in the ACC and HCs’ mI and Cr in the PC were higher than that of other interaction effects. In addition, the concentrations of BDds’ Glx and Cr in the PC and HCs’ mI in the ACC were statistically significant lower than that of other interaction effects. These findings point to region-related abnormalities of cerebral metabolites across subjects with BDd and UDd.
机译：先前的研究表明，患有双相抑郁症（BDd）或单相抑郁症（UDd）的患者具有脑代谢异常。这些异常可能源于大脑区域中灰质的多个子区域。招募了13名BDd患者，20名UDd患者和20名健康对照（HC），以调查这些异常情况。从4个子区域测量了5种脑代谢产物（谷氨酸-谷氨酰胺（Glx），N-乙酰天门冬氨酸（NAA），胆碱（Cho），肌醇（mI），肌酸（Cr），顶叶皮层（PC）的绝对浓度（灰质的内侧额叶皮质（mPFC），前扣带回皮质（ACC），后扣带回皮质（PCC）和顶叶皮质（PC））。评估了大脑代谢产物跨灰质子区域的主要作用和相互作用。例如，BDd中的Glx明显高于UDd，等等。如相互作用分析所示，存在一些相互作用效应。 ACC中BDds的Glx，Cho，Cr浓度以及PC中HCs的mI和Cr浓度高于其他相互作用效应。此外，ACC中PC和HCs mI中BDds Glx和Cr的浓度在统计学上显着低于其他相互作用效应。这些发现指向BDd和UDd受试者大脑代谢产物的区域相关异常。

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