• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Scientific Reports >Methylation of a panel of genes in peripheral blood leukocytes is associated with colorectal cancer
【2h】

Methylation of a panel of genes in peripheral blood leukocytes is associated with colorectal cancer

机译：外周血白细胞中一组基因的甲基化与大肠癌有关

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The relationship between the DNA methylation status of the CpG islands of multiple genes in blood leukocytes in CRC susceptibility and prognosis, as well as possible interactions with dietary factors on CRC risk are unclear. We carried out a case-control study including 421 CRC patients and 506 controls to examine the associations between six genes (AOX-1, RARB2, RERG, ADAMTS9, IRF4, and FOXE-1), multiple CpG site methylation (MCSM) and susceptibility to CRC. High-level MCSM (MCSM-H) was defined as methylation of greater than or equal to 2 of 5 candidate genes (except for RARB2); low-level MCSM (MCSM-L) was when 1 candidate gene was methylated; non-MCSM was when none of the candidate genes were methylated. Blood cell-derived DNA methylation status was detected using methylation-sensitive high-resolution melting analysis. The hypermethylation status of each individual gene was statistically significantly associated with CRC. MCSM status was also associated with CRC (OR = 1.54, 95% CI: 1.15–2.05, P = 0.004). We observed interactions between a high level of dietary intake of cereals, pungent food, and stewed fish with brown sauce, age (older than 60 yrs), smoking and hypermethylation on risk of CRC. MCSM in peripheral blood DNA may be an important biomarker for susceptibility to CRC.
机译：CRC易感性和预后与血液白细胞中多个基因的CpG岛的DNA甲基化状态之间的关系以及与饮食因素对CRC风险的可能相互作用尚不清楚。我们进行了一项病例对照研究，包括421名CRC患者和506名对照，以检查六个基因（AOX-1，RARB2，RERG，ADAMTS9，IRF4和FOXE-1），多CpG位点甲基化（MCSM）和易感性之间的关联CRC。高级MCSM（MCSM-H）定义为大于或等于5个候选基因中的2个的甲基化（RARB2除外）；低水平MCSM（MCSM-L）是1个候选基因被甲基化时；非MCSM是当所有候选基因均未甲基化时。使用甲基化敏感的高分辨率解链分析检测血细胞来源的DNA甲基化状态。每个单独基因的高甲基化状态在统计学上与CRC显着相关。 MCSM状态也与CRC相关（OR（= 1.54，95％CI：1.15-2.05，P = 0.004）。我们观察到高水平的谷物，辛辣食物和炖鱼配褐色酱，年龄（大于60岁），吸烟和甲基化过度可能导致CRC风险之间的相互作用。外周血DNA中的MCSM可能是CRC易感性的重要生物标志物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号