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首页> 美国卫生研究院文献>Scientific Reports >FOXO3 variants are beneficial for longevity in Southern Chinese living in the Red River Basin: A case-control study and meta-analysis
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FOXO3 variants are beneficial for longevity in Southern Chinese living in the Red River Basin: A case-control study and meta-analysis

机译：FOXO3变体有益于红河流域华南地区的长寿：病例对照研究和荟萃分析

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Forkhead box class O (FOXO) transcription factors play a crucial role in longevity across species. Several polymorphisms in FOXO3 were previously reported to be associated with human longevity. However, only one Chinese replication study has been performed so far. To verify the role of FOXO3 in southern Chinese in the Red River Basin, a community-based case-control study was conducted, and seven polymorphisms were genotyped in 1336 participants, followed by a meta-analysis of eight case-control studies that included 5327 longevity cases and 4608 controls. In our case-control study, we found rs2802288*A and rs2802292*G were beneficial to longevity after Bonferroni correction (pallele = 0.005, OR = 1.266; pallele = 0.026, OR = 1.207). In addition, in the longevity group, carriers with rs2802288*A and rs2802292*G presented reduced HbA1c (p = 0.001), and homozygotes of rs2802292*GG presented improved HOMA–IR (p = 0.014). The meta-analysis further revealed the overall contribution of rs2802288*A and rs2802292*G to longevity. However, our stratified analysis revealed that rs2802292*G might act more strongly in Asians than Europeans, for enhancement of longevity. In conclusion, our study provides convincing evidence for a significant association between the rs2802288*A and rs2802292*G gene variants in FOXO3 and human longevity, and adds the Southern Chinese in the Red River Basin to the growing number of human replication populations.
机译：O型前叉箱（FOXO）转录因子在跨物种寿命中起着至关重要的作用。以前有报道说FOXO3中有几种多态性与人类寿命有关。但是，到目前为止，仅进行了一项中文复制研究。为了验证FOXO3在红河流域华南地区的作用，进行了一项基于社区的病例对照研究，并在1336名参与者中对7种多态性进行了基因分型，随后对包括5327种情况在内的八项病例对照研究进行了荟萃分析。长寿案件和4608控件。在我们的病例对照研究中，我们发现在Bonferroni校正后，rs2802288 * A和rs2802292 * G对延年益寿（pallele = 0.005，OR = 1.266； pallele = 0.026，OR = 1.207）。另外，在长寿组中，带有rs2802288 * A和rs2802292 * G的携带者表现出降低的HbA1c（p = 0.001），而rs2802292 * GG的纯合子表现出改善的HOMA-IR（p = 0.014）。荟萃分析进一步揭示了rs2802288 * A和rs2802292 * G对寿命的总体贡献。但是，我们的分层分析显示，rs2802292 * G在亚洲人中的作用可能比欧洲人强，以延长寿命。总而言之，我们的研究提供了令人信服的证据，表明FOXO3中的rs2802288 * A和rs2802292 * G基因变异与人类寿命之间存在显着关联，并将红河流域的华南人添加到越来越多的人类复制种群中。

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