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首页> 美国卫生研究院文献>Journal of Korean Medical Science >Serotypes and antimicrobial susceptibility in clinical isolates of Haemophilus influenzae from Korean children in prevaccination era.
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Serotypes and antimicrobial susceptibility in clinical isolates of Haemophilus influenzae from Korean children in prevaccination era.

机译：接种前时代韩国儿童流感嗜血杆菌临床分离株的血清型和抗菌药敏性。

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Fifty-five strains of Haemophilus influenzae recovered at a children's hospital in Korea from 1992 through 1997, were analyzed for serotype and antibiotic resistance. Antimicrobial susceptibility was tested by broth dilution method. Among the 55 strains, 26 were from normally sterile body fluids, of which 17 were from the immunocompetent children. Spectrum in the immunocompetent included meningitis (47%), bacteremic pneumonia (18%), and bacteremia without focus (35%). Three (12%) of 26 invasive infections were caused by non-type b: one type d and two type f. Nine of 29 non-sterile body fluid isolates belonged to one of encapsulted serotypes: four a, two c, one of each of b, d and e. Thirty two (58%) strains were resistant to ampicillin, and all of which produced beta-lactamase. All of the strains were highly susceptible to amoxicillin/clavulanate, cefixime, cefuroxime, azithromycin and ciprofloxacin, while 1 (2%), 7 (13%), 4 (7%) and 4 (7%) strains were intermediate to cefprozil, cefaclor, loracarbef, and clarithromycin, respectively. The serotype distribution of H. influenzae in Korean children is similar to those in developed countries before the introduction of Hib conjugate vaccine, and ampicillin resistance rate is among the highest published to date.
机译：从1992年至1997年在韩国一家儿童医院回收的55株流感嗜血杆菌进行了血清型和抗生素耐药性分析。通过肉汤稀释法测试抗菌敏感性。在55个菌株中，有26个来自正常无菌体液，其中17个来自具有免疫能力的儿童。具有免疫功能的频谱包括脑膜炎（47％），细菌性肺炎（18％）和无病菌菌血症（35％）。 26种浸润性感染中有3种（12％）是由非b型引起的：一种是d型，两种是f型。 29个非无菌体液分离株中有9个属于封装的血清型之一：4个a，2个c，b，d和e之一。 32株（58％）菌株对氨苄西林具有抗性，所有菌株均产生β-内酰胺酶。所有菌株均对阿莫西林/克拉维酸盐，头孢克​​肟，头孢呋辛，阿奇霉素和环丙沙星高度敏感，而1（2％），7（13％），4（7％）和4（7％）菌株在头孢曲唑中间，头孢克洛，洛拉卡培和克拉霉素。在引入Hib结合疫苗之前，韩国儿童中流感嗜血杆菌的血清型分布与发达国家相似，氨苄青霉素耐药率是迄今为止公布的最高水平。

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