首页> 外国专利> Pneumococcal polysaccharide serotype 1,4,5,6B, 7F, 9V, 14 and 23F conjugated to D proteins (derived from non-typeable Haemophilus influenzae); 18C polysaccharide pneumococcal serotype conjugated to transporter tetanus toxoid protein; 19F Polysaccharide Pneumococcal Serotype Conjugated to Transporter Diphtheria Toxoid Protein (SYNFLORIX - Conjugated Polysaccharide Pneumococcal Vaccine (Adsorbed)

Pneumococcal polysaccharide serotype 1,4,5,6B, 7F, 9V, 14 and 23F conjugated to D proteins (derived from non-typeable Haemophilus influenzae); 18C polysaccharide pneumococcal serotype conjugated to transporter tetanus toxoid protein; 19F Polysaccharide Pneumococcal Serotype Conjugated to Transporter Diphtheria Toxoid Protein (SYNFLORIX - Conjugated Polysaccharide Pneumococcal Vaccine (Adsorbed)

机译：与D蛋白结合的肺炎球菌多糖血清型1、4、5、6B，7F，9V，14和23F（来源于不可分型的流感嗜血杆菌）;与转运破伤风类毒素蛋白缀合的18C多糖肺炎球菌血清型;与转运白喉类毒素蛋白结合的19F多糖肺炎球菌血清型（SYNFLORIX-结合多糖肺炎球菌疫苗（吸附）

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摘要

A novel surface exposed protein of Haemophilus influenzae or related Haemophilus species is described. The protein named protein D is an Ig receptor for human IgD and has an apparent molecular weight of 42,000. Protein D can be detected in all of 116 encapsulated and non-encapsulated isolates of H. influenzae studied. The protein from all strains shows in addition to the same apparent molecular weight immunogenic similarities since protein D from all strains interacts with three different mouse monoclonal antibodies and monoclonal human IgD. A method for purification of protein D is described. Cloning of the protein D gene from H. influenzae in E. coli is described as well as the nucleotide sequence and the deduced amino acid sequence.

机译：描述了一种新型的流感嗜血杆菌或相关嗜血杆菌表面暴露蛋白。名为蛋白质D的蛋白质是人类IgD的Ig受体，其表观分子量为42,000。可以在所研究的116株流感嗜血杆菌的所有封装和非封装分离物中检测到D蛋白。由于所有菌株的蛋白质D与三种不同的小鼠单克隆抗体和单克隆人IgD相互作用，因此所有菌株的蛋白质除具有相同的表观分子量免疫原性相似性外，还显示出其他相似之处。描述了一种纯化蛋白D的方法。描述了在大肠杆菌中来自流感嗜血杆菌的蛋白D基因的克隆，以及核苷酸序列和推导的氨基酸序列。

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公开/公告号LU91609I2

专利类型
公开/公告日2009-11-24

原文格式PDF
申请/专利权人 FORSGREN ARNE;
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申请/专利号LU20090091609C
发明设计人
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申请日2009-09-24
分类号A61K39;A61K38;A61K39/102;A61P31/04;C07K14/005;C07K14/195;C07K14/285;C07K14/41;C07K14/705;C07K16;C07K16/12;C07K19;C12N1/21;C12N5/10;C12N15/02;C12N15/09;C12N15/31;C12P21;C12P21/08;C12R1/19;C12R1/21;C12R1/91;G01N33/53;G01N33/569;G01N33/577;
国家 LU
入库时间 2022-08-21 18:45:50

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