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首页> 外文期刊>Infection and immunity >Immunogenicity of conjugate vaccines consisting of pneumococcal capsular polysaccharide types 6B, 14, 19F, and 23F and a meningococcal outer membrane protein complex.
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Immunogenicity of conjugate vaccines consisting of pneumococcal capsular polysaccharide types 6B, 14, 19F, and 23F and a meningococcal outer membrane protein complex.

机译：由6B，14、19F和23F型肺炎球菌荚膜多糖和脑膜炎球菌外膜蛋白复合物组成的结合疫苗的免疫原性。

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摘要

In an effort to prepare pneumococcal (Pn) capsular polysaccharide (Ps) vaccines that would be immunogenic in infants, covalent conjugates were prepared for Pn types 6B, 14, 19F, and 23F. Each Ps type was covalently bound to an outer membrane protein complex from Neisseria meningitidis serogroup B and evaluated for immunogenicity in mice and infant monkeys. The conjugates induced specific anti-Ps antibody responses in mice and in infant rhesus and African green monkeys; a conjugate of 6B and outer membrane protein complex was immunogenic at Ps doses as low as 20 ng. Although low levels of the Pn group-common cell wall polysaccharide were present in all type-specific Ps preparations, anti-cell wall polysaccharide responses induced by covalent conjugates were < 1% of the total anti-Ps response after two doses of vaccine. In contrast, the anti-cell wall polysaccharide response of a noncovalent conjugate represented 41% of the anti-Ps response after two doses. Relative T-cell dependence, a requirement for the human target population of infants less than 18 months old, was demonstrated for all four Pn Ps conjugates in an athymic mouse model. Therefore, these Pn Ps-outer membrane protein complex conjugate vaccines are excellent candidates for evaluation in human infants.
机译：为了制备对婴儿具有免疫原性的肺炎球菌（Pn）荚膜多糖（Ps）疫苗，针对6B，14、19F和23F型Pn制备了共价结合物。每种Ps类型都与脑膜炎奈瑟氏球菌血清群B的外膜蛋白复合物共价结合，并评估了小鼠和幼猴的免疫原性。结合物在小鼠，婴儿恒河猴和非洲绿猴中诱导特异性抗Ps抗体反应。 6B和外膜蛋白复合物的结合物在Ps剂量低至20 ng时具有免疫原性。尽管在所有类型特异性Ps制剂中均存在低水平的Pn基团常见的细胞壁多糖，但是在两次疫苗后，共价结合物诱导的抗细胞壁多糖应答小于总抗Ps应答的1％。相反，非共价缀合物的抗细胞壁多糖应答代表两次给药后抗Ps应答的41％。对于无胸腺小鼠模型中的所有四种Pn Ps缀合物，都证明了相对T细胞依赖性（对人类目标人群不到18个月大的婴儿的要求）。因此，这些Pn Ps-外膜蛋白复合物偶联疫苗是用于人类婴儿评估的极佳候选者。

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