首页> 美国卫生研究院文献>Journal of Korean Medical Science >Colorectal adenocarcinoma as a second malignant neoplasm following rhabdomyosarcoma of the urinary bladder: a case report.
【2h】

Colorectal adenocarcinoma as a second malignant neoplasm following rhabdomyosarcoma of the urinary bladder: a case report.

机译:大肠腺癌是膀胱横纹肌肉瘤继发于膀胱恶性肿瘤的第二例恶性肿瘤。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

Following improvements in therapy for childhood malignancies, the striking increase in survival rate over the past 30 years has led to the increase risk of developing second malignant neoplasms (SMNs). We report a case of colorectal carcinoma as a SMN, following treatment for rhabdomyosarcoma. The patient was diagnosed with rhabdomyosarcoma of the urinary bladder at his age of three years, and developed adenocarcinoma in the colon 13 years later. Histologic examination of the surgical specimen revealed adenocarcinoma involving the rectosigmoid area with radiation colitis in its background. The tumor cells showed strong immunoreactivity for p53 protein, suggesting the role of irradiation and p53 mutation in carcinogenesis. This case emphasizes the need for dose observation in survivors of early childhood malignancies treated with radiation and multiagent chemotherapy.
机译:随着儿童恶性肿瘤治疗方法的改进,过去30年中存活率的惊人增长导致罹患第二恶性肿瘤(SMN)的风险增加。我们报告横纹肌肉瘤治疗后结直肠癌作为SMN一例。该患者在3岁时被诊断出患有膀胱横纹肌肉瘤,并在13年后在结肠中发展为腺癌。手术标本的组织学检查显示腺癌累及直肠乙状结肠区域,背景为放射性结肠炎。肿瘤细胞显示出对p53蛋白的强免疫反应性,提示辐射和p53突变在癌变中的作用。该病例强调需要对接受放射治疗和多药化疗的儿童早期恶性肿瘤幸存者进行剂量观察。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号