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首页> 美国卫生研究院文献>Molecular and Clinical Oncology >Comparison of the diagnostic performance of 18F-fluorothymidine versus 18F-fluorodeoxyglucose positron emission tomography on pulmonary lesions: A meta analysis
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Comparison of the diagnostic performance of 18F-fluorothymidine versus 18F-fluorodeoxyglucose positron emission tomography on pulmonary lesions: A meta analysis

机译：18F-氟胸苷与18F-氟脱氧葡萄糖正电子发射断层显像对肺部病变的诊断性能比较：荟萃分析

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A pulmonary lesion is an extremely common and clinically challenging disorder worldwide, and an accurate diagnosis of lung cancer is crucial for early treatment and management. The aim of the present study was to perform a comprehensive meta analysis to compare the diagnostic performance of 18F-fluorothymidine (18F-FLT) positron emission tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG) PET in evaluating patients with pulmonary lesions. Relevant studies were identified using the PubMed, EMBASE and Cochrane library databases. The pooled estimated sensitivity, specificity, positive-likelihood ratio, negative-likelihood ratio, and diagnostic odds ratio (DOR) for 18F-FLT PET versus 18F-FDG PET were calculated as the main outcome measures. Summary receiver operating characteristic curves were also constructed by Meta-Disk 1.4 software using a Mose's constant of linear model. The meta analysis showed that 18F-FLT PET had a higher specificity (0.70; 95% CI, 0.61–0.77), but lower sensitivity (0.81; 95% CI, 0.74–0.87) compared to 18F-FDG PET (0.50; 95% CI, 0.41–0.58 for specificity; 0.92; 95% CI 0.86–0.95 for sensitivity). For DOR, 18F-FLT PET (12.58; 95% CI, 6.81–23.24) was higher compared to 18F-FDG PET (10.72; 95% CI, 5.51–20.87). The area under the curve was 0.8592 and 0.9240 for 18F-FLT PET and 18F-FDG PET, respectively (Z=0.976, P>0.05). In conclusion, 18F-FLT PET and 18F-FDG PET had good diagnostic performance for the overall assessment of pulmonary lesions, and 18F-FLT PET had a higher specificity compared to 18F-FDG PET, but was less sensitive than 18F-FDG PET. Therefore, 18F-FLT and 18F-FDG together could add diagnostic confidence for pulmonary lesions.
机译：肺部病变是世界范围内极为常见且临床上具有挑战性的疾病，准确诊断肺癌对早期治疗和管理至关重要。本研究的目的是进行全面的荟萃分析，以比较 18 F-氟胸苷（ 18 F-FLT）正电子发射断层显像（PET）与 18 F-氟脱氧葡萄糖（ 18 F-FDG）PET在评估肺部病变患者中的价值。使用PubMed，EMBASE和Cochrane库数据库鉴定了相关研究。 18 F-FLT PET与 18 F-FDG PET的汇总估计灵敏度，特异性，正似然比，负似然比和诊断比值比（DOR）被计算为主要结局指标。 Meta-Disk 1.4软件还使用Mose常数模型建立了摘要接收器工作特性曲线。荟萃分析显示，与 sup> 18 F-FLT PET相比， 18 F-PET的特异性更高（0.70； 95％CI，0.61-0.77），但敏感性较低（0.81； 95％CI，0.74-0.87）。 sup> 18 F-FDG PET（0.50； 95％CI，特异性为0.41-0.58； 0.92； 95％CI为0.86-0.95）。对于DOR， 18 F-FLT PET（12.58; 95％CI，6.81–23.24）高于 18 F-FDG PET（10.72; 95％CI，5.51） –20.87）。 18 F-FLT PET和 18 F-FDG PET的曲线下面积分别为0.8592和0.9240（Z = 0.976，P> 0.05）。总之， 18 F-FLT PET和 18 F-FDG PET对肺部病变的整体评估具有良好的诊断性能，而 18 F与 18 F-FDG PET相比，-FLT PET具有更高的特异性，但敏感性却低于 18 F-FDG PET。因此， 18 F-FLT和 18 F-FDG一起可以增加对肺部病变的诊断信心。

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