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首页> 美国卫生研究院文献>Journal of Neurophysiology >A novel instrumented multipeg running wheel system Step-Wheel for monitoring and controlling complex sequential stepping in mice
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A novel instrumented multipeg running wheel system Step-Wheel for monitoring and controlling complex sequential stepping in mice

机译：一种新颖的装备有装备的多轮式跑步轮系统Step-Wheel用于监视和控制小鼠中的复杂顺序踏步

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Motor control is critical in daily life as well as in artistic and athletic performance and thus is the subject of intense interest in neuroscience. Mouse models of movement disorders have proven valuable for many aspects of investigation, but adequate methods for analyzing complex motor control in mouse models have not been fully established. Here, we report the development of a novel running-wheel system that can be used to evoke simple and complex stepping patterns in mice. The stepping patterns are controlled by spatially organized pegs, which serve as footholds that can be arranged in adjustable, ladder-like configurations. The mice run as they drink water from a spout, providing reward, while the wheel turns at a constant speed. The stepping patterns of the mice can thus be controlled not only spatially, but also temporally. A voltage sensor to detect paw touches is attached to each peg, allowing precise registration of footfalls. We show that this device can be used to analyze patterns of complex motor coordination in mice. We further demonstrate that it is possible to measure patterns of neural activity with chronically implanted tetrodes as the mice engage in vigorous running bouts. We suggest that this instrumented multipeg running wheel (which we name the Step-Wheel System) can serve as an important tool in analyzing motor control and motor learning in mice.
机译：运动控制在日常生活以及艺术和运动表现中都至关重要，因此成为神经科学的主题。运动障碍的小鼠模型已被证明可用于许多方面的研究，但尚未完全建立用于分析小鼠模型中复杂运动控制的适当方法。在这里，我们报告了一种新颖的行走轮系统的开发，该系统可用于唤起小鼠的简单和复杂的踩踏模式。踩踏模式由空间排列的钉子控制，这些钉子可以作为可调节的梯形配置的立脚点。老鼠从壶嘴喝水时奔跑，从而提供奖励，而轮子以恒定速度转动。因此，不仅可以在空间上而且可以在时间上控制小鼠的踩踏方式。每个钉子上都装有一个检测爪子触碰的电压传感器，可以精确记录脚步。我们表明，该设备可用于分析小鼠中复杂运动协调的模式。我们进一步证明，当小鼠进行剧烈的奔跑时，可以用慢性植入的四极来测量神经活动的模式。我们建议，这种装有仪器的Multipeg行走轮（我们将其称为“步轮系统”）可以作为分析小鼠运动控制和运动学习的重要工具。

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