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首页> 美国卫生研究院文献>Bioscience Reports >Investigation of ICOS CD28 and CD80 polymorphisms with the risk of hepatocellular carcinoma: a case–control study in eastern Chinese population
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Investigation of ICOS CD28 and CD80 polymorphisms with the risk of hepatocellular carcinoma: a case–control study in eastern Chinese population

机译：患有肝细胞癌的ICOSCD28和CD80基因多态性调查：病例对照研究在中国东部人群中

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Single nucleotide polymorphisms (SNPs) in immune related gene may influence the susceptibility of cancer. We selected inducible T cell costimulator (ICOS) rs4404254 T>C, rs10932029 T>C, CD28 rs3116496 T>C and CD80 rs7628626 C>A SNPs and assessed the potential relationship of these SNPs with hepatocellular carcinoma (HCC) risk. A total of 584 HCC cases and 923 healthy controls were recruited. And SNPscan™ genotyping assay was used to obtain the genotypes of ICOS, CD28 and CD80 polymorphisms. We found that ICOS rs10932029 T>C polymorphism significantly increased the risk of HCC (additive model: adjusted odds ratio (OR), 1.59; 95% confidence interval (CI), 1.13–2.22; P=0.007; homozygote model: adjusted OR, 1.12; 95% CI, 0.31–4.03; P=0.867; dominant model: adjusted OR, 1.58; 95% CI, 1.14–2.19; P=0.007 and recessive model: adjusted OR, 1.02; 95% CI, 0.28–3.68; P=0.974). However, ICOS rs4404254 T>C, CD28 rs3116496 T>C and CD80 rs7628626 C>A SNPs were not associated with the risk of HCC. To evaluate the effects of ICOS rs10932029 T>C on HCC risk according to different age, gender, chronic hepatitis B virus (HBV) infection, tobacco consumption and drinking status, we carried out a stratification analysis. We found that ICOS rs10932029 T>C polymorphism might increase the risk of HCC in male, ≥53 years, never smoking, never drinking and non-chronic HBV infection subgroups. Our study highlights that ICOS rs10932029 T>C polymorphism may confer the susceptibility to HCC. It may be beneficial to explore the relationship between variants in immune related genes and the development of HCC.
机译：免疫相关基因中的单核苷酸多态性（SNP）可能影响癌症的易感性。我们选择了诱导性T细胞共刺激物（ICOS）rs4404254 T> C，rs10932029 T> C，CD28 rs3116496 T> C和CD80 rs7628626 C> A SNP，并评估了这些SNP与肝细胞癌（HCC）风险的潜在关系。总共招募了584例HCC病例和923例健康对照。然后使用SNPscan™基因分型法获得ICOS，CD28和CD80多态性的基因型。我们发现ICOS rs10932029 T> C多态性显着增加了HCC的风险（加性模型：校正后的优势比（OR）为1.59； 95％置信区间（CI）为1.13–2.22； P = 0.007；纯合子模型：校正后的OR， 1.12； 95％CI，0.31-4.03； P = 0.867；优势模型：调整后的OR，1.58； 95％CI，1.14-2.19； P = 0.007和隐性模型：调整后的OR，1.02； 95％CI，0.28-3.68； P = 0.974）。但是，ICOS rs4404254 T> C，CD28 rs3116496 T> C和CD80 rs7628626 C> A SNP与肝癌风险无关。为了评估ICOS rs10932029 T> C对不同年龄，性别，慢性乙型肝炎病毒（HBV）感染，吸烟和饮酒状况的影响，对HCC风险的影响，我们进行了分层分析。我们发现，ICOS rs10932029 T> C多态性可能增加男性，≥53岁，从不吸烟，从不饮酒和非慢性HBV感染亚组的HCC风险。我们的研究突出表明，ICOS rs10932029 T> C多态性可能赋予肝癌易感性。探索免疫相关基因的变异与肝癌的发展之间的关系可能是有益的。

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