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Fish trypsins: potential applications in biomedicine and prospects for production

机译：鱼胰蛋白酶：在生物医学中的潜在应用和生产前景

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In fishes, trypsins are adapted to different environmental conditions, and the biochemical and kinetic properties of a broad variety of native isoforms have been studied. Proteolytic enzymes remain in high demand in the detergent, food, and feed industries; however, our analysis of the literature showed that, in the last decade, some fish trypsins have been studied for the synthesis of industrial peptides and for specific biomedical uses as antipathogenic agents against viruses and bacteria, which have been recently patented. In addition, innovative strategies of trypsin administration have been studied to ensure that trypsins retain their properties until they exert their action. Biomedical uses require the production of high-quality enzymes. In this context, the production of recombinant trypsins is an alternative. For this purpose, E. coli-based systems have been tested for the production of fish trypsins; however, P. pastoris-based systems also seem to show great potential in the production of fish trypsins with higher production quality. On the other hand, there is a lack of information regarding the specific structures, biochemical and kinetic properties, and characteristics of trypsins produced using heterologous systems. This review describes the potential uses of fish trypsins in biomedicine and the enzymatic and structural properties of native and recombinant fish trypsins obtained to date, outlining some prospects for their study.
机译：在鱼类中，胰蛋白酶适应于不同的环境条件，并且已经研究了多种天然同工型的生物化学和动力学特性。在洗涤剂，食品和饲料工业中，对蛋白水解酶的需求仍然很高。但是，我们对文献的分析表明，在最近的十年中，已经研究了一些鱼胰蛋白酶，用于合成工业肽和用于特定的生物医学用途，作为抗病毒和细菌的抗病原体，最近已获得专利。另外，已经研究了胰蛋白酶给药的创新策略，以确保胰蛋白酶保持其性质直至发挥作用。生物医学用途需要生产高质量的酶。在这种情况下，重组胰蛋白酶的生产是替代方案。为此，已经对基于大肠杆菌的系统进行了鱼胰蛋白酶生产的测试。但是，基于巴斯德毕赤酵母的系统在生产更高质量的鱼胰蛋白酶方面似乎也显示出巨大的潜力。另一方面，缺乏关于使用异源系统生产的胰蛋白酶的具体结构，生化和动力学特性以及特性的信息。这篇综述描述了鱼胰蛋白酶在生物医学中的潜在用途以及迄今为止获得的天然和重组鱼胰蛋白酶的酶学和结构性质，概述了它们的研究前景。

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