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首页> 美国卫生研究院文献>Genome Biology and Evolution >Reconstructed Lost Native American Populations from Eastern Brazil Are Shaped by Differential Jê/Tupi Ancestry
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Reconstructed Lost Native American Populations from Eastern Brazil Are Shaped by Differential Jê/Tupi Ancestry

机译：来自巴西东部的失落的美国原住民人口重建受到不同的Jê/ Tupi祖先的塑造

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After the colonization of the Americas by Europeans and the consequent Trans-Atlantic Slave Trade, most Native American populations in eastern Brazil disappeared or went through an admixture process that configured a population composed of three main genetic components: the European, the sub-Saharan African, and the Native American. The study of the Native American genetic history is challenged by the lack of availability of genome-wide samples from Native American populations, the technical difficulties to develop ancient DNA studies, and the low proportions of the Native American component in the admixed Brazilian populations (on average 7%). We analyzed genome-wide data of 5,825 individuals from three locations of eastern Brazil: Salvador (North-East), Bambui (South-East), and Pelotas (South) and we reconstructed populations that emulate the Native American groups that were living in the 16th century around the sampling locations. This genetic reconstruction was performed after local ancestry analysis of the admixed Brazilian populations, through the rearrangement of the Native American haplotypes into reconstructed individuals with full Native American ancestry (51 reconstructed individuals in Salvador, 45 in Bambui, and 197 in Pelotas). We compared the reconstructed populations with nonadmixed Native American populations from other regions of Brazil through haplotype-based methods. Our results reveal a population structure shaped by the dichotomy of Tupi-/Jê-speaking ancestry related groups. We also show evidence of a decrease of the diversity of nonadmixed Native American groups after the European contact, in contrast with the reconstructed populations, suggesting a reservoir of the Native American genetic diversity within the admixed Brazilian population.
机译：在欧洲人对美洲进行殖民化以及随之而来的跨大西洋奴隶贸易之后，巴西东部的大多数美洲原住民种群消失或经历了混合过程，该过程构成了由三个主要遗传成分组成的种群：欧洲人，撒哈拉以南非洲人，以及美国原住民。缺乏来自美洲原住民群体的全基因组样本，开发古代DNA研究的技术困难以及在混杂的巴西人口中美国原住民成分的比例低​​等挑战了对美国原住民遗传历史的研究。平均7％）。我们分析了巴西东部三个地区（萨尔瓦多（东北），班贝（东南）和佩洛塔斯（南部））的5,825个个体的全基因组数据，并重建了模拟居住在巴西的美洲原住民群体的种群。 16世纪左右的采样地点。通过对美洲原住民的单倍型重排为具有完整美国原住民血统的重建个体（萨尔瓦多有51名重建个体，班布伊有45名重建个体，佩洛塔斯有197位个体），在对混合的巴西人口进行本地祖先分析之后，进行了这种基因重建。通过基于单倍型的方法，我们将重建的人口与巴西其他地区的非混合美洲原住民人口进行了比较。我们的结果揭示了由图皮语/吉语祖先相关群体的二分法形成的人口结构。我们还显示，与重建后的种群相比，欧洲接触后非混合的美洲原住民群体的多样性降低了，这表明在混合的巴西种群中美洲原住民遗传多样性的储备。

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