How to assess the effectiveness of nasal influenza vaccines? Role and measurement of sIgA in mucosal secretions

机译：如何评估鼻流感疫苗的有效性？ sIgA在粘膜分泌中的作用和测定

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Secretory IgAs (sIgA) constitute the principal isotype of antibodies present in nasal and mucosal secretions. They are secreted by plasma cells adjacent to the mucosal epithelial cells, the site where infection occurs, and are the main humoral mediator of mucosal immunity. Mucosally delivered vaccines, such as live attenuated influenza vaccine (LAIV), are able to mimic natural infection without causing disease or virus transmission and mainly elicit a local immune response. The measurement of sIgA concentrations in nasal swab/wash and saliva samples is therefore a valuable tool for evaluating their role in the effectiveness of such vaccines. Here, we describe two standardized assays (enzyme‐linked immunosorbent assay and microneutralization) available for the quantification of sIgA and discuss the advantages and limitations of their use.

机译：分泌型IgA（sIgA）构成鼻腔和粘膜分泌物中存在的抗体的主要同种型。它们由与粘膜上皮细胞相邻的浆细胞分泌，它们是发生感染的部位，并且是粘膜免疫的主要体液介质。粘膜递送的疫苗，例如减毒活疫苗（LAIV），能够模仿自然感染而不会引起疾病或病毒传播，并且主要引起局部免疫反应。因此，鼻拭子/洗液和唾液样品中sIgA浓度的测量是评估其在此类疫苗效力中的作用的宝贵工具。在这里，我们描述了可用于sIgA定量的两种标准化测定（酶联免疫吸附测定和微中和），并讨论了其使用的优点和局限性。

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期刊名称 Influenza and Other Respiratory Viruses
作者
Elena Gianchecchi; Alessandro Manenti; Otfried Kistner; Claudia Trombetta; Ilaria Manini; Emanuele Montomoli;
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作者单位

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年(卷),期 2019(13),5
年度 2019
页码 429–437
总页数 9
原文格式 PDF
正文语种
中图分类病毒传染病;人体病毒学（致病病毒）;病毒（滤过性病毒）;
关键词
enzyme‐linked immunosorbent assay influenza vaccines influenza virus mucosal immunity secretory IgAs;

机译：酶联免疫吸附测定;流感疫苗;流感病毒;粘膜免疫;分泌型IgA;

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专利

1. How to assess the effectiveness of nasal influenza vaccines? Role and measurement of sIgA in mucosal secretions [J] . Elena Gianchecchi, Alessandro Manenti, Otfried Kistner, Influenza and other respiratory viruses. . 2019,第5期

机译：如何评估鼻流感疫苗的有效性？ sIgA在粘膜分泌中的作用和测量
2. Mucosal [SIgA] and serum [IgG] immunologic responses in the community after a single intra-nasal immunization with a new inactivated trivalent influenza vaccine [J] . Greenbaum E, Furst A, Kiderman A, Vaccine . 2002,第7a8期

机译：用新型灭活的三价流感疫苗进行一次鼻内免疫后，社区的粘膜[SIgA]和血清[IgG]免疫反应
3. Vaccine effectiveness in pandemic influenza - primary care reporting (VIPER): An observational study to assess the effectiveness of the pandemic influenza a (H1N1)v vaccine [J] . SimpsonC.R., RitchieL.D., RobertsonC., Health technology assessment: HTA . 2010,第34期

机译：大流行性流感疫苗的有效性-初级保健报告（VIPER）：一项评估A型大流行性流感（H1N1）v疫苗有效性的观察性研究
4. HIV mucosal vaccine: nasal immunization with rBCG-V3Jl induces a long-term V3J1 peptide-specific neutralizing immunity in Thl- and Th2-deficient condition [C] . Hironobu Goto, Takachika Hiroi, Manabu Ynagita, International Symposium on Tonsils and Mucosal Barriers of Upper Airways . 2003

机译：HIV粘膜疫苗：用RBCG-V3JL的鼻免疫诱导TH2缺乏条件下的长期V3J1肽特异性中和免疫
5. The Administration of Intranasal Live Attenuated Influenza Vaccine Induces Changes in the Nasal Microbiota and Nasal Epithelium Gene Expression Profile. [D] . Tarabichi, Yasir. 2015

机译：鼻内减毒活疫苗的使用诱导鼻微生物群和鼻上皮基因表达谱的变化。
6. Long-Lasting Mucosal and Systemic Immunity against Influenza A Virus Is Significantly Prolonged and Protective by Nasal Whole Influenza Immunization with Mucosal Adjuvant N3 and DNA-Plasmid Expressing Flagellin in Aging In- and Outbred Mice [O] . Jorma Hinkula, Sanna Nyström, Claudia Devito, 2019

机译：鼻粘膜佐剂N3和DNA-质粒表达鞭毛蛋白在老化的近交和近交小鼠中对甲型流感病毒的持久粘膜和全身免疫显着延长并具有保护作用。
7. How to assess the effectiveness of nasal influenza vaccines? Role and measurement of sIgA in mucosal secretions [O] . Elena Gianchecchi, Alessandro Manenti, Otfried Kistner, 2019

机译：如何评估鼻流感疫苗的有效性？ SIGA在粘膜分泌中的作用和测量
8. Comparison of the Effectiveness of Trivalent Inactivated Influenza Vaccine and Live, Attenuated Influenza Vaccine in Preventing Influenza-Like Illness among US Service Members, 2006-2009. [R] . Phillips, C. J., Woolpert, T., Sevick, C., 2012

机译：2006 - 2009年美国服务成员中三价灭活流感疫苗和活减毒流感疫苗预防流感样疾病的效果比较。

How to assess the effectiveness of nasal influenza vaccines? Role and measurement of sIgA in mucosal secretions

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