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首页> 美国卫生研究院文献>Journal of Lipid Research >Plasma levels of lecithin:cholesterol acyltransferase and risk of future coronary artery disease in apparently healthy men and women: a prospective case-control analysis nested in the EPIC-Norfolk population study
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Plasma levels of lecithin:cholesterol acyltransferase and risk of future coronary artery disease in apparently healthy men and women: a prospective case-control analysis nested in the EPIC-Norfolk population study

机译：显然健康的男性和女性的血浆卵磷脂：胆固醇酰基转移酶水平和未来冠状动脉疾病的风险：EPIC-Norfolk人群研究中的前瞻性病例对照分析

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摘要

LCAT plays a key role in the maturation of HDL, as evidenced by low HDL-cholesterol levels in carriers of deleterious mutations in LCAT. However, the role of LCAT in atherosclerosis is unclear. We set out to study this in a prospective study. Plasma LCAT levels, which strongly correlate with LCAT activity, were measured in baseline nonfasting samples of 933 apparently healthy men and women who developed coronary artery disease (CAD) and 1,852 matched controls who remained free of CAD during 6 year follow-up. LCAT levels did not differ between cases and controls but were higher in women than men. Stratification into LCAT quartiles revealed a positive association with plasma LDL-cholesterol and triglyceride levels in the unexpected absence of an association with HDL-cholesterol. In mixed-gender analyses, the odds ratio (OR) for future CAD in the highest LCAT quartile versus the lowest was 1.00 [confidence interval (CI): 0.76–1.29, P for linearity = 0.902], although opposite trends were observed in men and women. In fact, high LCAT levels were associated with an increased CAD risk in women (unadjusted OR 1.45, CI: 0.94–2.22, P for linearity = 0.036). In contrast to our studies in carriers of LCAT mutations, the current data show that low LCAT plasma levels are not associated with increased atherosclerosis in the general population.
机译：LCAT在HDL成熟中起着关键作用，LCAT有害突变携带者中的HDL-胆固醇水平低证明了这一点。但是，LCAT在动脉粥样硬化中的作用尚不清楚。我们开始在前瞻性研究中对此进行研究。血浆LCAT水平与LCAT活性密切相关，在基线非禁食样本中测量了933名明显健康的患有冠状动脉疾病（CAD）的男性和女性和1,852名在6年的随访期间保持无CAD的对照组的基线非禁食样品。病例和对照之间的LCAT水平无差异，但女性高于男性。 LCAT四分位数的分层显示出与血浆LDL-胆固醇和甘油三酯水平呈正相关，而出乎意料的是与HDL-胆固醇无关联。在混合性别分析中，未来的CAD在最高的LCAT四分位数与最低的四分位数中的优势比（OR）为1.00 [置信区间（CI）：0.76-1.29，线性P = 0.902]，尽管在男性中观察到相反的趋势和女人。实际上，高LCAT水平与女性CAD风险增加相关（未调整OR 1.45，CI：0.94-2.22，线性P = 0.036）。与我们对LCAT突变携带者的研究相反，当前数据表明低LCAT血浆水平与普通人群中动脉粥样硬化的增加无关。

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