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Caffeic acid phenethyl ester as a remedial agent for reproductive functions and oxidative stress-based pathologies of gonads

机译:咖啡酸苯乙酯作为性腺生殖功能和氧化应激病理的治疗剂

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摘要

In recent years, the studies on the roles of caffeic acid phenethyl ester (CAPE) in several disease models and cell cultures are tremendously growing. It is such a great molecule that was used by ancient times to ameliorate some diseases and nowadays, it is used by modern medicine to test the effectiveness. In this mini-review article, the protection capability of CAPE, as a liposoluble antioxidant and a potent nuclear factor kappa B inhibitor, on oxidative and non-oxidative ovary, and testis damages has been summarized. In view of our laboratory findings/experience and those reported in the hitherto literature, we suggest that CAPE possesses protective effects for pathologies of the reproductive organs induced by untoward effects of harmful molecules such as free oxygen radicals, pesticides, methotrexate, and MK-801 (dizocilpine).
机译:近年来,关于咖啡酸苯乙酯(CAPE)在几种疾病模型和细胞培养中的作用的研究正在迅速发展。它是一种伟大的分子,在古代曾被用来缓解某些疾病,如今,它已被现代医学用于检验其有效性。在这篇小型综述文章中,总结了CAPE作为脂溶性抗氧化剂和有效的核因子κB抑制剂对氧化性和非氧化性卵巢以及睾丸的保护作用。鉴于我们的实验室发现/经验以及迄今为止的文献报道,我们建议CAPE对有害分子如有害的自由基如氧自由基,杀虫剂,甲氨蝶呤和MK-801的不良影响所致的生殖器官病理学具有保护作用。 (地佐西平)。

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