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首页> 美国卫生研究院文献>Regenerative Biomaterials >A novel akermanite/poly (lactic-co-glycolic acid) porous composite scaffold fabricated via a solvent casting-particulate leaching method improved by solvent self-proliferating process
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A novel akermanite/poly (lactic-co-glycolic acid) porous composite scaffold fabricated via a solvent casting-particulate leaching method improved by solvent self-proliferating process

机译：通过溶剂自扩散法改进的溶剂流铸-颗粒浸出法制备的新型钙钛矿/聚乳酸-乙醇酸多孔复合支架

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Desirable scaffolds for tissue engineering should be biodegradable carriers to supply suitable microenvironments mimicked the extracellular matrices for desired cellular interactions and to provide supports for the formation of new tissues. In this work, a kind of slightly soluble bioactive ceramic akermanite (AKT) powders were aboratively selected and introduced in the PLGA matrix, a novel l-lactide modified AKT/poly (lactic-co-glycolic acid) (m-AKT/PLGA) composite scaffold was fabricated via a solvent casting-particulate leaching method improved by solvent self-proliferating process. The effects of m-AKT contents on properties of composite scaffolds and on MC3T3-E1 cellular behaviors in vitro have been primarily investigated. The fabricated scaffolds exhibited three-dimensional porous networks, in which homogenously distributed cavities in size of 300–400 μm were interconnected by some smaller holes in a size of 100–200 μm. Meanwhile, the mechanical structure of scaffolds was reinforced by the introduction of m-AKT. Moreover, alkaline ionic products released by m-AKT could neutralize the acidic degradation products of PLGA, and the apatite-mineralization ability of scaffolds could be largely improved. More valuably, significant promotions on adhesion, proliferation, and differentiation of MC3T3-E1 have been observed, which implied the calcium, magnesium and especially silidous ions released sustainably from composite scaffolds could regulate the behaviors of osteogenesis-related cells.
机译：用于组织工程的理想支架应该是可生物降解的载体，以提供适合细胞外基质的合适微环境，以实现所需的细胞相互作用，并为新组织的形成提供支持。在这项工作中，我们选择了一种微溶的生物活性陶瓷钙锰矿（AKT）粉末，并将其引入PLGA基质中，这是一种新型的l-丙交酯改性的AKT /聚乳酸-乙醇酸（m-AKT / PLGA）复合支架是通过溶剂自扩散工艺改进的溶剂浇铸-颗粒浸出法制备的。初步研究了m-AKT含量对复合支架性能和体外MC3T3-E1细胞行为的影响。制成的脚手架具有三维多孔网络，其中大小为300-400μm的均匀分布的空腔通过大小为100-200μm的较小孔相互连接。同时，通过引入m-AKT增强了支架的机械结构。此外，m-AKT释放的碱性离子产物可以中和PLGA的酸性降解产物，并可以大大提高支架的磷灰石矿化能力。更有价值的是，已观察到对MC3T3-E1粘附，增殖和分化的显着促进作用，这暗示着复合支架可持续释放的钙，镁，尤其是硅离子可以调节成骨相关细胞的行为。

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