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Potential coordination role between O-GlcNAcylation and epigenetics

机译：O-GlcNAcylation和表观遗传学之间的潜在协调作用

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摘要

Dynamic changes of the post-translational O-GlcNAc modification (O-GlcNAcylation) are controlled by O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) and the glycoside hydrolase O-GlcNAcase (OGA) in cells. O-GlcNAcylation often occurs on serine (Ser) and threonine (Thr) residues of the specific substrate proteins via the addition of O-GlcNAc group by OGT. It has been known that O-GlcNAcylation is not only involved in many fundamental cellular processes, but also plays an important role in cancer development through various mechanisms. Recently, accumulating data reveal that O-GlcNAcylation at histones or non-histone proteins can lead to the start of the subsequent biological processes, suggesting that O-GlcNAcylation as ‘protein code’ or ‘histone code’ may provide recognition platforms or executive instructions for subsequent recruitment of proteins to carry out the specific functions. In this review, we summarize the interaction of O-GlcNAcylation and epigenetic changes, introduce recent research findings that link crosstalk between O-GlcNAcylation and epigenetic changes, and speculate on the potential coordination role of O-GlcNAcylation with epigenetic changes in intracellular biological processes.
机译：翻译后O-GlcNAc修饰（O-GlcNAcylation）的动态变化由细胞中O-连接的β-N-乙酰基氨基葡萄糖（O-GlcNAc）转移酶（OGT）和糖苷水解酶O-GlcNAcase（OGA）控制。 O-GlcNAcylation通常通过OGT加入O-GlcNAc基团而在特定底物蛋白的丝氨酸（Ser）和苏氨酸（Thr）残基上发生。已知O-GlcNAcylation不仅参与许多基本的细胞过程，而且还通过各种机制在癌症发展中起重要作用。最近，越来越多的数据表明，组蛋白或非组蛋白的O-GlcNAcylation可以导致随后的生物学过程的开始，这表明O-GlcNAcylation作为“蛋白代码”或“组蛋白代码”可能为识别提供平台或执行指令。随后募集蛋白质以执行特定功能。在这篇综述中，我们总结了O-GlcNAcylation与表观遗传变化之间的相互作用，介绍了将O-GlcNAcylation与表观遗传变化之间的串扰联系起来的最新研究发现，并推测了O-GlcNAcylation与细胞内生物过程中表观遗传变化的潜在协调作用。

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