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Complexity and biosemiotics in evolutionary ecology of zoonotic infectious agents

机译:人畜共患病传染原进化生态学中的复杂性和生物符号学

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摘要

More is not automatically better. Generation and accumulation of information reflecting the complexity of zoonotic diseases as ecological systems do not necessarily lead to improved interpretation of the obtained information and understanding of these complex systems. The traditional conceptual framework for analysis of diseases ecology is neither designed for, nor adaptable enough, to absorb the mass of diverse sources of relevant information. The multidirectional and multidimensional approaches to analyses form an inevitable part in defining a role of zoonotic pathogens and animal hosts considering the complexity of their inter‐relations. And the more data we have, the more involved the interpretation needs to be. The keyword for defining the roles of microbes as pathogens, animals as hosts, and environmental parameters as infection drivers is “functional importance.” Microbes can act as pathogens toward their host only if/when they recognize the animal organism as the target. The same is true when the host recognizes the microbe as a pathogen rather than harmless symbiont based on the context of its occurrence in that host. Here, we propose conceptual tools developed in the realm of the interdisciplinary sciences of complexity and biosemiotics for extending beyond the currently dominant mindset in ecology and evolution of infectious diseases. We also consider four distinct hierarchical levels of perception guiding how investigators can approach zoonotic agents, as a subject of their research, representing differences in emphasizing particular elements and their relations versus more unified systemic approaches.
机译:越多越多越多越好。信息的产生和积累反映出人畜共患疾病作为生态系统的复杂性,并不一定会导致对获得的信息的更好的解释和对这些复杂系统的理解。疾病生态学分析的传统概念框架既没有设计,也没有足够的适应性,无法吸收大量相关信息的来源。考虑到相互关系的复杂性,多方向和多维分析方法是确定人畜共患病原体和动物宿主作用的必然部分。而且,我们拥有的数据越多,解释就需要涉及的越多。定义微生物作为病原体,动物作为宿主,环境参数作为感染驱动因素的关键词是“功能重要性”。微生物只有在/当他们认识到动物有机体为目标时,才可以作为对其宿主的病原体。当宿主基于微生物在该宿主中的存在而将其识别为病原体而不是无害的共生体时,情况也是如此。在这里,我们提出了在复杂性和生物符号学的跨学科科学领域中开发的概念工具,以扩展到生态学和传染病演变的当前主导思想之外。我们还考虑了四个不同的层次感知层次,指导研究人员如何研究人畜共患病主体,这是他们研究的主题,代表了在强调特定要素及其关系方面与统一的系统方法之间的差异。

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