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首页> 美国卫生研究院文献>Physiological Reports >Cardiovascular and cerebral hemodynamics during exercise and recovery in obese individuals as a function of their fitness status
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Cardiovascular and cerebral hemodynamics during exercise and recovery in obese individuals as a function of their fitness status

机译：肥胖个体运动和恢复期间的心血管和脑血流动力学与他们的健康状况的关系

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The aim of this study was to compare cardiovascular hemodynamics and cerebral oxygenation/perfusion (COP) during and after maximal incremental exercise in obese individuals according to their aerobic fitness versus age‐matched healthy controls (AMHC). Fifty‐four middle–aged obese (OB) and 16 AMHC were recruited. Maximal cardiopulmonary function (gas exchange analysis), cardiac hemodynamics (impedance cardiography), and left frontal COP (near‐infrared spectroscopy: NIRS) were measured continuously during a maximal incremental ergocycle test. During recovery, reoxygenation/perfusion rate (ROPR: oxyhemoglobin: ΔO2Hb, deoxyhemoglobin: ΔHHb and total hemoglobin: ΔtHb; with NIRS) was also measured. Obese participants (OB, n = 54) were divided into two groups according to the median V˙O2 peak: the low‐fit obese (LF‐OB, n = 27) and the high‐fit obese (HF‐OB, n = 27). During exercise, end tidal pressure of CO 2 (PETCO 2), and style="fixed-case">COP (ΔO2Hb, Δ style="fixed-case">HHb and ΔtHb) did not differ between groups ( style="fixed-case">OB, style="fixed-case"> LF‐ style="fixed-case">OB, style="fixed-case"> HF‐ style="fixed-case">OB, style="fixed-case"> AMHC). During recovery, style="fixed-case">PETCO 2 and style="fixed-case">ROPR (ΔO2Hb, Δ style="fixed-case">HHb and ΔtHb) were similar between the groups ( style="fixed-case">OB, style="fixed-case"> LF‐ style="fixed-case">OB, style="fixed-case"> HF‐ style="fixed-case">OB, style="fixed-case"> AMHC). During exercise and recovery, cardiac index was lower (P < 0.05) in style="fixed-case">LF‐ style="fixed-case">OB versus the other two groups ( style="fixed-case">HF‐ style="fixed-case">OB, style="fixed-case"> AMHC). As well, systolic blood pressure was higher during exercise in the style="fixed-case">OB, style="fixed-case"> LF‐ style="fixed-case">OB and style="fixed-case">HF‐ style="fixed-case">OB groups versus style="fixed-case">AMHC (P < 0.05). When compared to style="fixed-case">AMHC, obese individuals ( style="fixed-case">OB, style="fixed-case"> LF‐ style="fixed-case">OB, style="fixed-case"> HF‐ style="fixed-case">OB) have a similar cerebral vasoreactivity by style="fixed-case">CO 2 and cerebral hemodynamics during exercise and recovery, but a higher systolic blood pressure during exercise. Higher fitness in obese subjects ( style="fixed-case">HF‐ style="fixed-case">OB) seems to preserve their cardiopulmonary and cardiac function during exercise and recovery.
机译：这项研究的目的是根据有氧健身能力与年龄匹配的健康对照者（AMHC）比较肥胖个体最大增量运动期间和之后的心血管血液动力学和脑氧合/灌注（COP）。招募了54名中年肥胖（OB）和16名AMHC。在最大增量人体工学循环测试期间，连续测量最大心肺功能（气体交换分析），心脏血液动力学（阻抗心动图）和左额叶COP（近红外光谱：NIRS）。在恢复期间，还测量了复氧/灌注率（ROPR：氧合血红蛋白：ΔO2Hb，脱氧血红蛋白：ΔHHb和总血红蛋白：ΔtHb；使用NIRS）。根据中位数 V ˙ O 2 峰值：低适应肥胖者（LF-OB，n = 27）和高适应肥胖者（HF-OB，n = 27）。在运动过程中，CO 2（PETCO 2）的最终潮气压力和 style =“ fixed-case”> COP （ΔO2Hb，Δ style =“ fixed-case”> HH b和ΔtHb）在各组之间没有差异（ style =“ fixed-case”> OB ， style =“ fixed-case”> LF - style =“ fixed-case” > OB ， style =“ fixed-case”> HF - style =“ fixed-case”> OB ， style =“ fixed-case”> AMHC ）。在恢复期间， style =“ fixed-case”> PETCO 2和 style =“ fixed-case”> ROPR （ΔO2Hb，Δ style =“ fixed-case”> HH b和ΔtHb）在两个组（ style =“ fixed-case”> OB ， style =“ fixed-case”> LF - style = “ fixed-case”> OB ， style =“ fixed-case”> HF - style =“ fixed-case”> OB ， style =“ fixed -case“> AMHC ）。在运动和恢复期间， style =“ fixed-case”> LF - style =“ fixed-case”> OB 的心脏指数低于其他两个（P <0.05）组（ style =“ fixed-case”> HF - style =“ fixed-case”> OB ， style =“ fixed-case”> AMHC ） 。同样，在运动过程中， style =“ fixed-case”> OB ， style =“ fixed-case”> LF - style =“ fixed -case“> OB 和 style =” fixed-case“> HF - style =” fixed-case“> OB 组与 style =” fixed- case“> AMHC （P <0.05）。与 style =“ fixed-case”> AMHC 相比，肥胖个体（ style =“ fixed-case”> OB ， style =“ fixed-case”> LF < / span>- style =“ fixed-case”> OB ， style =“ fixed-case”> HF - style =“ fixed-case”> OB ）在运动和恢复期间的 style =“ fixed-case”> CO 2的脑血管反应性和脑血流动力学相似，但运动时的收缩压较高。肥胖受试者的较高适应性（ style =“ fixed-case”> HF - style =“ fixed-case”> OB ）似乎可以在运动和恢复过程中保持其心肺功能和心功能。

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