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Anti-BCMA CAR-T cells for treatment of plasma cell dyscrasia: case report on POEMS syndrome and multiple myeloma

机译：抗BCMA CAR-T细胞治疗浆细胞异位症：POEMS综合征和多发性骨髓瘤的病例报告

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BackgroundPOEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome still has no standard treatment. On the basis that both POEMS syndrome and myeloma have an underlying plasma cell dyscrasia, anti-myeloma therapy can be expected to be useful for POEMS syndrome. Chimeric antigen receptor T (CAR-T) cells targeting B cell maturation antigen (BCMA) has been used in the treatment of relapsed and refractory multiple myeloma (RRMM). No POEMS syndrome cases treated with anti-BCMA CAR-T cells have been reported.

机译：背景POEMS（多发性神经病，器质性肿大，内分泌病，单克隆丙种球蛋白病和皮肤变化）综合征仍没有标准治疗方法。基于POEMS综合征和骨髓瘤均具有潜在的浆细胞发育不良，抗骨髓瘤治疗有望用于POEMS综合征。靶向B细胞成熟抗原（BCMA）的嵌合抗原受体T（CAR-T）细胞已用于治疗复发性和难治性多发性骨髓瘤（RRMM）。没有报道用抗BCMA CAR-T细胞治疗过POEMS综合征的病例。

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期刊名称 Journal of Hematology Oncology
作者
Jinhuan Xu; Qiuxiang Wang; Hao Xu; Chaojiang Gu; Lijun Jiang; Jue Wang; Di Wang; Bin Xu; Xia Mao; Jin Wang; Zhiqiong Wang; Yi Xiao; Yicheng Zhang; Chunrui Li; Jianfeng Zhou;
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年(卷),期 2018(11),-1
年度 2018
页码 128
总页数 9
原文格式 PDF
正文语种
中图分类肿瘤学;血液学检验;
关键词
Chimeric antigen receptor T cells B cell maturation antigen Remissions Multiple myeloma POEMS syndrome;

机译：嵌合抗原受体T细胞;B细胞成熟抗原;缓解;多发性骨髓瘤;POEMS综合征;

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1. Successful Treatment of Relapsed/Refractory Extramedullary Multiple Myeloma With Anti-BCMA CAR-T Cell Therapy Followed by Haploidentical Hematopoietic Stem Cell Transplantation: A Case Report and a Review of the Contemporary Literature [J] . Ying Qian, Zijun Qian, Xiujie Zhao, Frontiers in Medicine . 2021,第a期

机译：用抗BCMA Car-T细胞疗法的复发/难治性髓外骨髓瘤的成功治疗随后是Haploidentical造血干细胞移植：案例报告和对当代文学的审查
2. Anti-BCMA CAR-T Cell Therapy in Relapsed or Refractory Multiple Myeloma Patients with Impaired Renal Function [J] . Shao-long HE, Yu-hang CHENG, Di WANG, 当代医学科学(英文) . 2021,第003期

机译：Anti-BCMA CAR-T Cell Therapy in Relapsed or Refractory Multiple Myeloma Patients with Impaired Renal Function
3. A simple and robust clinical manufacturing process for the ex-vivo expansion of autologous T cells genetically engineered to express an anti-BCMA chimeric antigen receptor (CAR) for the treatment of multiple myeloma [J] . Alden Ladd, Graham Lilley, Mingli Li, Journal for ImmunoTherapy of Cancer . 2015,第S2期

机译：用于基因工程改造以表达抗BCMA嵌合抗原受体（CAR）的自体T细胞体外扩增的简单而强大的临床制造工艺，用于治疗多发性骨髓瘤
4. In-vitro Testing of Arsenic Sulfide Nanoparticles for the Treatment of Multiple Myeloma Cells [C] . P. Balaz, J. Sedlak, M. Pastorek, NSTI nanotechnology conference and expo;Nanotech conference expo;NSTI-Nanotech 2011;TechConnect world annual conference expo . 2011

机译：硫化砷纳米粒子在体外治疗多发性骨髓瘤细胞治疗的体外测试
5. A Heavy-Chain-Only CAR-T Cell Therapy Elicits Comparable Antitumor Response Compared with Canonical CAR-T Cells [D] . Wang, Guanmeng . 2019

机译：与规范汽车-T细胞相比，仅重链的Cel-T细胞疗法引发了可比的抗肿瘤反应
6. Successful Treatment of Relapsed/Refractory Extramedullary Multiple Myeloma With Anti-BCMA CAR-T Cell Therapy Followed by Haploidentical Hematopoietic Stem Cell Transplantation: A Case Report and a Review of the Contemporary Literature [O] . Ying Qian, Zijun Qian, Xiujie Zhao, 2021

机译：成功处理复发/难治性髓外骨髓瘤与抗BCMA Car-T细胞疗法其次是Haploidentical造血干细胞移植：案例报告和对当代文学的审查
7. Anti-BCMA CAR-T cells for treatment of plasma cell dyscrasia: case report on POEMS syndrome and multiple myeloma [O] . Jinhuan Xu, Qiuxiang Wang, Hao Xu, 2018

机译：用于治疗血浆细胞多塞的抗BCMA CAR-T细胞：关于诗歌综合征和多发性骨髓瘤的病例报告

Anti-BCMA CAR-T cells for treatment of plasma cell dyscrasia: case report on POEMS syndrome and multiple myeloma

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