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首页> 美国卫生研究院文献>Pharmacology Research Perspectives >A pilot study on the incidence of severe photosensitivity reactions leading to hospitalization linked to topical ketoprofen and other medications in selected European regions
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A pilot study on the incidence of severe photosensitivity reactions leading to hospitalization linked to topical ketoprofen and other medications in selected European regions

机译：在部分欧洲地区进行的严重光敏反应导致与住院的酮洛芬和其他药物相关的住院治疗的发生率的初步研究

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The aim of this study was to assess the prevalence of exposure to topical nonsteroidal anti‐inflammatory drugs (NSAIDs), particularly ketoprofen, in a convenience sample of the population, to obtain estimates of the incidence of severe photosensitivity leading to hospitalization, and to assess causative factors in three catchment areas: the Paris metropolitan area, the Lombardy region (Italy) and the Prague area. All cases of severe photosensitivity not explained by underlying conditions and admitted to hospitals in the selected areas were included in the study. Controls were patients consecutively admitted to hospitals, in the same areas, for an acute condition or for an elective procedure not suspected of being related to medication use. From October 2012 to September 2013, 920 controls were recruited (median age 44 years, 50.8% females); 8 severe photosensitivity cases were reported in the population aged 18–74 years of the 3 geographical areas during the 1‐year surveillance period, corresponding to an incidence rate of 4.81 cases per 10 million person‐years (95% confidence interval – CI, 2.07–9.48). Six controls reported 1‐month exposure to topical ketoprofen, with an estimated prevalence of 0.65% (95% CI, 0.24–1.42). The population attributable risk for severe photosensitivity reactions linked to ketoprofen was 11.92% (95% CI, −0.12–52.99). This study was conducted in selected European areas and showed that the incidence of severe photosensitivity reactions leading to hospitalization as well as the exposure rate to topical ketoprofen were low. Among topical NSAIDs, topical ketoprofen was the leading cause of photosensitivity reactions but accounted for a limited number of hospitalized cases. Probably most of the relevant reactions were managed in the outpatient setting and a community based case–control study is advisable.
机译：这项研究的目的是评估在方便人群中局部非甾体类抗炎药（NSAIDs）尤其是酮洛芬暴露的患病率，以获得导致住院的严重光敏性发生率的估计值，并评估三个集水区的致病因素：巴黎市区，伦巴第地区（意大利）和布拉格地区。这项研究包括了所有严重的光敏性病例，这些病例没有用基本条件解释，并且入选了选定地区的医院。对照组是在同一地区连续住院的急性病患者或因怀疑与药物使用无关的选择性手术而入院的患者。从2012年10月到2013年9月，招募了920名控制人员（中位年龄44岁，女性50.8％）；在1年的监测期内，在3个地理区域的18-74岁年龄段中报告了8例严重的光敏性病例，对应的发病率是每1000万人年4.81例（95％置信区间– CI，2.07 –9.48）。六个对照者报告局部酮洛芬暴露1个月，估计患病率为0.65％（95％CI，0.24–1.42）。与酮洛芬有关的严重光敏反应的人群归因于风险为11.92％（95％CI，-0.12-52.99）。这项研究是在欧洲部分地区进行的，结果表明，导致住院的严重光敏反应发生率以及局部酮洛芬的暴露率较低。在局部NSAID中，局部酮洛芬是光敏反应的主要原因，但占住院病例的数量有限。可能大多数相关反应是在门诊患者中进行的，建议进行基于社区的病例对照研究。

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