• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Nucleic Acids Research >CLIPZ: a database and analysis environment for experimentally determined binding sites of RNA-binding proteins
【2h】

CLIPZ: a database and analysis environment for experimentally determined binding sites of RNA-binding proteins

机译：CLIPZ：用于实验确定RNA结合蛋白结合位点的数据库和分析环境

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The stability, localization and translation rate of mRNAs are regulated by a multitude of RNA-binding proteins (RBPs) that find their targets directly or with the help of guide RNAs. Among the experimental methods for mapping RBP binding sites, cross-linking and immunoprecipitation (CLIP) coupled with deep sequencing provides transcriptome-wide coverage as well as high resolution. However, partly due to their vast volume, the data that were so far generated in CLIP experiments have not been put in a form that enables fast and interactive exploration of binding sites. To address this need, we have developed the CLIPZ database and analysis environment. Binding site data for RBPs such as Argonaute 1-4, Insulin-like growth factor II mRNA-binding protein 1-3, TNRC6 proteins A-C, Pumilio 2, Quaking and Polypyrimidine tract binding protein can be visualized at the level of the genome and of individual transcripts. Individual users can upload their own sequence data sets while being able to limit the access to these data to specific users, and analyses of the public and private data sets can be performed interactively. CLIPZ, available at , aims to provide an open access repository of information for post-transcriptional regulatory elements.
机译：mRNA的稳定性，定位和翻译速率受多种RNA结合蛋白（RBP）的调节，这些蛋白可以直接或在指导RNA的帮助下找到其靶标。在用于绘制RBP结合位点的实验方法中，交联和免疫沉淀（CLIP）与深度测序相结合可提供整个转录组的覆盖范围以及高分辨率。但是，部分原因是由于其庞大的数量，到目前为止，CLIP实验中生成的数据并未以能够快速，交互地探索结合位点的形式放置。为了满足这一需求，我们开发了CLIPZ数据库和分析环境。 RBP的结合位点数据，例如Argonaute 1-4，胰岛素样生长因子II mRNA结合蛋白1-3，TNRC6蛋白AC，Pumilio 2，Quaking和Polypyrimidine管道结合蛋白，可以在基因组水平上观察到。个人成绩单。单个用户可以上载自己的序列数据集，同时可以将特定用户限制对这些数据的访问，并且可以交互方式执行公共和私有数据集的分析。 CLIPZ可以从处获得，其目的是为转录后监管要素提供开放的信息存储库。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号