• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Nanoscale Research Letters >RGD-conjugated silica-coated gold nanorods on the surface of carbon nanotubes for targeted photoacoustic imaging of gastric cancer
【2h】

RGD-conjugated silica-coated gold nanorods on the surface of carbon nanotubes for targeted photoacoustic imaging of gastric cancer

机译：碳纳米管表面上的RGD共轭二氧化硅涂层的金纳米棒用于胃癌的靶向光声成像

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Herein, we reported for the first time that RGD-conjugated silica-coated gold nanorods on the surface of multiwalled carbon nanotubes were successfully used for targeted photoacoustic imaging of in vivo gastric cancer cells. A simple strategy was used to attach covalently silica-coated gold nanorods (sGNRs) onto the surface of multiwalled carbon nanotubes (MWNTs) to fabricate a hybrid nanostructure. The cross-linked reaction occurred through the combination of carboxyl groups on the MWNTs and the amino group on the surface of sGNRs modified with a silane coupling agent. RGD peptides were conjugated with the sGNR/MWNT nanostructure; resultant RGD-conjugated sGNR/MWNT probes were investigated for their influences on viability of MGC803 and GES-1 cells. The nude mice models loaded with gastric cancer cells were prepared, the RGD-conjugated sGNR/MWNT probes were injected into gastric cancer-bearing nude mice models via the tail vein, and the nude mice were observed by an optoacoustic imaging system. Results showed that RGD-conjugated sGNR/MWNT probes showed good water solubility and low cellular toxicity, could target in vivo gastric cancer cells, and obtained strong photoacoustic imaging in the nude model. RGD-conjugated sGNR/MWNT probes will own great potential in applications such as targeted photoacoustic imaging and photothermal therapy in the near future.
机译：在此，我们首次报道了在多壁碳纳米管表面上的RGD-共轭二氧化硅涂层的金纳米棒已成功用于体内胃癌细胞的靶向光声成像。使用一种简单的策略将共价二氧化硅涂覆的金纳米棒（sGNR）连接到多壁碳纳米管（MWNT）的表面上，以制造杂化纳米结构。交联反应是通过MWNTs上的羧基与经硅烷偶联剂改性的sGNRs表面上的氨基结合而发生的。 RGD肽与sGNR / MWNT纳米结构偶联；研究了RGD共轭的sGNR / MWNT探针对MGC803和GES-1细胞活力的影响。制备载有胃癌细胞的裸鼠模型，将RGD-缀合的sGNR / MWNT探针通过尾静脉注射到带有胃癌的裸鼠模型中，并通过光声成像系统观察裸鼠。结果表明，RGD偶联的sGNR / MWNT探针显示出良好的水溶性和低细胞毒性，可以靶向体内胃癌细胞，并在裸鼠模型中获得了强大的光声成像。结合RGD的sGNR / MWNT探针将在不久的将来在诸如靶向光声成像和光热疗法等应用中拥有巨大潜力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号