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A central resource for accurate allele frequency estimation from pooled DNA genotyped on DNA microarrays

机译：准确的等位基因频率估计的核心资源可根据在DNA微阵列上分型的DNA进行估算

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摘要

Analysing pooled DNA on microarrays is an efficient way to genotype hundreds of individuals for thousands of markers for genome-wide association. Although direct comparison of case and control fluorescence scores is possible, correction for differential hybridization of alleles is important, particularly for rare single nucleotide polymorphisms. Such correction relies on heterozygous fluorescence scores and requires the genotyping of hundreds of individuals to obtain sufficient estimates of the correction factor, completely negating any benefit gained by pooling samples. We explore the effect of differential hybridization on test statistics and provide a solution to this problem in the form of a central resource for the accumulation of heterozygous fluorescence scores, allowing accurate allele frequency estimation at no extra cost.

机译：在微阵列上分析合并的DNA是对成百上千的个体进行基因分型的有效方法，以用于数千个全基因组关联的标记。尽管可以直接比较病例和对照荧光评分，但校正等位基因差异杂交非常重要，特别是对于罕见的单核苷酸多态性。这种校正依赖于杂合荧光评分，并且需要对数百个个体进行基因分型以获得校正因子的足够估计，从而完全抵消了通过合并样品获得的任何好处。我们探索差异杂交对测试统计数据的影响，并以集中杂合荧光评分的中央资源的形式提供此问题的解决方案，无需任何额外费用即可进行准确的等位基因频率估算。

著录项

期刊名称 Nucleic Acids Research
作者
Claire L. Simpson; Joanne Knight; Lee M. Butcher; Valerie K. Hansen; Emma Meaburn; Leonard C. Schalkwyk; Ian W. Craig; John F. Powell; Pak C. Sham; Ammar Al-Chalabi;
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年(卷),期 2005(33),3
年度 2005
页码 e25
总页数 5
原文格式 PDF
正文语种
中图分类分子生物学;
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专利

1. A central resource for accurate allele frequency estimation from pooled DNA genotyped on DNA microarrays [J] . Ammar Al-Chalabi, Claire L. Simpson, Emma Meaburn, Nucleic acids research . 2005,第3期

机译：用于从DNA微阵列上基因分型的合并DNA准确估算等位基因频率的中央资源
2. PPC: an algorithm for accurate estimation of SNP allele frequencies in small equimolar pools of DNA using data from high density microarrays [J] . Brohede J, Dunne R, McKay JD, Nucleic Acids Research . 2005,第17期

机译：PPC：一种使用高密度微阵列数据准确估算小等摩尔DNA池中SNP等位基因频率的算法
3. PPC: an algorithm for accurate estimation of SNP allele frequencies in small equimolar pools of DNA using data from high density microarrays [J] . Garry N. Hannan, James D. McKay, Jesper Brohede, Nucleic acids research . 2005,第17期

机译：PPC：一种使用高密度微阵列数据准确估算小等摩尔DNA池中SNP等位基因频率的算法
4. A hierarchical learning approach to calibrate allele frequencies for SNP based genotyping of DNA pools [C] . Hellicar Andrew D., Smith Daniel, Rahman Ashfaqur, International Joint Conference on Neural Networks . 2014

机译：基于SNP的DNA库基因分型的等位基因频率校准的分层学习方法
5. Regulation of chromosomal DNA replication in Escherichia coli: I. Function of an N-terminal domain in DnaA oligomer formation. II. Biochemical and genetic studies of hyperactive dnaA alleles [D] . Simmons, Lyle Adair 2003

机译：大肠杆菌中染色体DNA复制的调节：I. DnaA寡聚物形成中的N末端结构域的功能。二。过度活跃的dnaA等位基因的生化和遗传研究
6. PPC: an algorithm for accurate estimation of SNP allele frequencies in small equimolar pools of DNA using data from high density microarrays [O] . Jesper Brohede, Rob Dunne, James D. McKay, 2005

机译：PPC：一种使用高密度微阵列数据准确估算小等摩尔DNA池中SNP等位基因频率的算法
7. A central resource for accurate allele frequency estimation from pooled DNA genotyped on DNA microarrays [O] . Simpson CL, Knight J, Butcher LM, 2005

机译：准确的等位基因频率估计的核心资源，可根据在DNA微阵列上分型的DNA进行估算

A central resource for accurate allele frequency estimation from pooled DNA genotyped on DNA microarrays

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